Neck circumference is associated with carotid intimal-media thickness but not with coronary artery calcium: Results from The ELSA-Brasil

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art_BAENA_Neck_circumference_is_associated_with_carotid_intimalmedia_thickness_2016.PDF (274.86 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
BAENA, C. P.
DUNCAN, B. B.
LIU, S.
Citação
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v.26, n.3, p.216-222, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and aims: It is uncertain whether neck circumference can be a risk indicator for subclinical atherosclerosis. We aimed to investigate their relationships measured by coronary artery calcium (CAC) and common carotid intima-media thickness (cc-IMT) with neck circumference in ELSA-Brasil. Methods and results: In cross-sectional and sex-specific analyses of 2266 women (50.6 +/- 8.4 yrs) and 1886 men (50.7 +/- 9.0 yrs) with both cc-IMT and CAC, free from previous cardiovascular disease at baseline, we built logistic models using diverse cut-off points for CAC score (0 vs >0, <100 vs >= 100, <400 vs >= 400 Agatston units) and cc-IMT (<75th percentile vs >= 75th; <90th percentile vs >= 90th) as dependent variables, after which adjustments for age and traditional cardiovascular risk factors were made. Mean neck circumference was 33.6 (+/- 2.4 cm) for women and 38.8 (+/- 2.6 cm) for men. In fully adjusted models including sociodemographic, cardiovascular risk factors and body-mass index and waist circumference, for each 1 standard deviation increase in neck circumference we found an odds ratio (OR, 95% CI) for IMT above the 75th percentile of (1.52, 1.16; 1.99) for women and (1.66, 1.28; 2.14) for men, and above the 90th cc-IMT percentile [1.66 (1.19; 2.32) for men but not for women [1.21 (0.80; 1.82)]. We found no association between neck circumference and CAC using different cut-off points (p > 0.05 for all). Conclusion: Neck circumference was significantly and independently associated with cc-IMT but not with CAC in women and men, indicating a possible effect of perivascular fat tissue on atherosclerosis.
Palavras-chave
Neck, Carotid artery diseases, Body fat distribution
URI
https://observatorio.fm.usp.br/handle/OPI/13884
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/51
Artigos e Materiais de Revistas Científicas - ODS/03