Experimental models of liver fibrosis

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Arquivos
art_YANGUAS_Experimental_models_of_liver_fibrosis_2016.PDF (2.21 MB)
Citações na Scopus
231
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
YANGUAS, Sara Crespo
COGLIATI, Bruno
WILLEBRORDS, Joost
MAES, Michael
COLLE, Isabelle
BOSSCHE, Bert van den
LECLERCQ, Isabelle
Citação
ARCHIVES OF TOXICOLOGY, v.90, n.5, p.1025-1048, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, chronic hepatitis virus infection and non-alcoholic steatohepatitis. A central event in liver fibrosis is the activation of hepatic stellate cells, which is triggered by a plethora of signaling pathways. Liver fibrosis can progress into more severe stages, known as cirrhosis, when liver acini are substituted by nodules, and further to hepatocellular carcinoma. Considerable efforts are currently devoted to liver fibrosis research, not only with the goal of further elucidating the molecular mechanisms that drive this disease, but equally in view of establishing effective diagnostic and therapeutic strategies. The present paper provides a state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research.
Palavras-chave
Liver fibrosis, Animal models, In vitro models, Hepatic stellate cells
URI
https://observatorio.fm.usp.br/handle/OPI/14248
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - LIM/37
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