Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/14342
Title: | Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia |
Authors: | SANANES, Nicolas; RODO, Carlota; PEIRO, Jose Luis; BRITTO, Ingrid Schwach Werneck; SANGI-HAGHPEYKAR, Haleh; FAVRE, Romain; JOAL, Arnaud; GAUDINEAU, Adrien; SILVA, Marcos Marques da; TANNURI, Uenis; ZUGAIB, Marcelo; CARRERAS, Elena; RUANO, Rodrigo |
Citation: | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, v.29, n.18, p.3030-3034, 2016 |
Abstract: | Objective: To evaluate the independent association of fetal pulmonary response and prematurity to postnatal outcomes after fetal tracheal occlusion for congenital diaphragmatic hernia. Methods: Fetal pulmonary response, prematurity (537 weeks at delivery) and extreme prematurity (532 weeks at delivery) were evaluated and compared between survivors and non-survivors at 6 months of life. Multivariable analysis was conducted with generalized linear mixed models for variables significantly associated with survival in univariate analysis. Results: Eighty-four infants were included, of whom 40 survived (47.6%) and 44 died (52.4%). Univariate analysis demonstrated that survival was associated with greater lung response (p = 0.006), and the absence of extreme preterm delivery (p = 0.044). In multivariable analysis, greater pulmonary response after FETO was an independent predictor of survival (aOR 1.87, 95% CI 1.08-3.33, p = 0.023), whereas the presence of extreme prematurity was not statistically associated with mortality after controlling for fetal pulmonary response (aOR 0.52, 95% CI 0.12-2.30, p = 0.367). Conclusion: Fetal pulmonary response after FETO is the most important factor associated with survival, independently from the gestational age at delivery. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - FM/MPE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/30 Artigos e Materiais de Revistas Científicas - LIM/57 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SANANES_Prematurity_and_fetal_lung_response_after_tracheal_occlusion_2016.PDF Restricted Access | publishedVersion (English) | 457.52 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.