Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/18968
Title: | Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells |
Authors: | MA, Yuting; ADJEMIAN, Sandy; MATTAROLLO, Stephen R.; YAMAZAKI, Takahiro; AYMERIC, Laetitia; YANG, Heng; CATANI, Joao Paulo Portela; HANNANI, Dalil; DURET, Helene; STEEGH, Kim; MARTINS, Isabelle; SCHLEMMER, Frederic; MICHAUD, Mickael; KEPP, Oliver; SUKKURWALA, Abdul Qader; MENGER, Laurie; VACCHELLI, Erika; DROIN, Nathalie; GALLUZZI, Lorenzo; KRZYSIEK, Roman; GORDON, Siamon; TAYLOR, Philip R.; ENDERT, Peter Van; SOLARY, Eric; SMYTH, Mark J.; ZITVOGEL, Laurence; KROEMER, Guido |
Citation: | IMMUNITY, v.38, n.4, p.729-741, 2013 |
Abstract: | The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells, however, remains a conundrum. We found that intra-tumoral CD11c(+)CD11b(+)Ly6C(hi) cells, which displayed some characteristics of inflammatory dendritic cells and included granulomonocytic precursors, were crucial for anthracycline-induced anticancer immune responses. ATP released by dying cancer cells recruited myeloid cells into tumors and stimulated the local differentiation of CD11c(+)CD11b(+)Ly6C(hi) cells. Such cells efficiently engulfed tumor antigens in situ and presented them to T lymphocytes, thus vaccinating mice, upon adoptive transfer, against a challenge with cancer cells. Manipulations preventing tumor infiltration by CD11c(+)CD11b(+)Ly6C(hi) cells, such as the local overexpression of ectonucleotidases, the blockade of purinergic receptors, or the neutralization of CD11b, abolished the immune system-dependent antitumor activity of anthracyclines. Our results identify a subset of tumor-infiltrating leukocytes as therapy-relevant antigen-presenting cells. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_MA_Anticancer_ChemotherapyInduced_Intratumoral_Recruitment_and_Differentiation_of_AntigenPresenting_2013.PDF Restricted Access | publishedVersion (English) | 2.39 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.