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https://observatorio.fm.usp.br/handle/OPI/18985
Title: | CCL2/CCR2-Dependent Recruitment of Functional AntigenPresenting Cells into Tumors upon Chemotherapy |
Authors: | MA, Yuting; MATTAROLLO, Stephen R.; ADJEMIAN, Sandy; YANG, Heng; AYMERIC, Laetitia; HANNANI, Dalil; CATANI, Joao Paulo Portela; DURET, Helene; TENG, Michele W. L.; KEPP, Oliver; WANG, Yidan; SISTIGU, Antonella; SCHULTZE, Joachim L.; STOLL, Gautier; GALLUZZI, Lorenzo; ZITVOGEL, Laurence; SMYTH, Mark J.; KROEMER, Guido |
Citation: | CANCER RESEARCH, v.74, n.2, p.436-445, 2014 |
Abstract: | The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell-and T-lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b(+)CD11c(+)Ly6C(high)Ly6G(-)MHCII(+) dendritic cell-like antigenpresenting cells (APC) into the tumor bed, but not into lymphoid organs. Accordingly, draining lymph nodes turned out to be dispensable for the proliferation of tumor antigen-specific T cells within neoplastic lesions as induced by anthracyclines. In addition, we found that tumors treated with anthracyclines manifest increased expression levels of the chemokine Ccl2. Such a response is important as neoplasms growing in Ccl2(-/-) mice failed to accumulate dendritic cell-like APCs in response to chemotherapy. Moreover, cancers developing in mice lacking Ccl2 or its receptor (Ccr2) exhibited suboptimal therapeutic responses to anthracycline-based chemotherapy. Altogether, our results underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy. (C) 2013 AACR. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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