Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients

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art_VEZOZZO_Strong_correlation_by_ultrasonography_of_hepatomegaly_and_the_2013.PDF (526.47 KB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2013
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CONTEXTO
Autores
CUNHA-SILVA, Marlone
FRANCA, Joao Italo Dias
Citação
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.17, n.2, p.150-155, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between patients with human immunodeficiency virus/hepatitis C virus co-infection (n = 16) versus hepatitis C virus mono-infection (n = 16). Methods: Each patient underwent abdominal ultrasound, and a specific evaluation was performed in order to detect findings consistent with chronic liver disease. Characterization of spleen size, liver structural pattern, diameter of the portal, spleen, and mesenteric veins was based on classical ultrasound parameters. Propensity score was used for control of selection bias and performed using binary logistic regression to generate a score for each patient. The Fisher and Mann-Whitney tests were used to evaluate categorical variables and continuous variables, respectively. Results: On univariate analysis right hepatic lobe size was larger in human immunodeficiency virus/hepatitis C virus patients (157.06 +/- 17.56 mm) compared to hepatitis C virus mono-infected patients (134.94 +/- 16.95 mm) (p = 0.0011). The left hepatic lobe was also significantly larger in human immunodeficiency virus/hepatitis C virus patients (115.88 +/- 22.69 mm) versus hepatitis C virus mono-infected patients (95.06 +/- 24.18 mm) (p = 0.0177). Also, there was a strong correlation between hepatomegaly and co-infection (p = 0.005). Conclusion: Human immunodeficiency virus infection was the primary variable influencing liver enlargement in this population. Hepatomegaly on ultrasound was more common among cirrhotic human immunodeficiency virus/hepatitis C virus co-infected patients than among cirrhotic hepatitis C virus mono-infected patients. This aspect is very important in the management of human immunodeficiency virus/hepatitis C virus co-infected patients, because screening for hepatocellular carcinoma is necessary in this population.
Palavras-chave
Ultrasonography, HIV/HCV co-infection, Hepatomegaly, Liver size, Cirrhosis
URI
https://observatorio.fm.usp.br/handle/OPI/1986
Referências
  1. Adinolfi LE, 2001, HEPATOLOGY, V33, P1358, DOI 10.1053/jhep.2001.24432
  2. Allory Y, 2000, HUM PATHOL, V31, P69, DOI 10.1016/S0046-8177(00)80201-4
  3. Amorosa V, 2005, JAIDS-J ACQ IMM DEF, V39, P557
  4. ASTAGNEAU P, 1990, ANN MED INTERNE, V141, P459
  5. Barreiro P, 2006, CLIN INFECT DIS, V42, P1032, DOI 10.1086/501021
  6. Bjornsson E, 2007, ARCH MED RES, V38, P621, DOI 10.1016/j.arcmed.2006.09.001
  7. Brown TT, 2005, ARCH INTERN MED, V165, P1179, DOI 10.1001/archinte.165.10.1179
  8. Cholet Franck, 2004, Gastroenterol Clin Biol, V28, P272, DOI 10.1016/S0399-8320(04)94918-4
  9. GOSINK BB, 1981, J CLIN ULTRASOUND, V9, P37, DOI 10.1002/jcu.1870090110
  10. GOTZBERGER M, 2006, SCHWEIZ RUNDSCH MED, V95, P183, DOI 10.1024/0369-8394.95.6.183
  11. HISLOP WS, 1983, Q J MED, V52, P232
  12. Kratzer W, 2003, J ULTRAS MED, V22, P1155
  13. Lesi OA, 2009, J NATL MED ASSOC, V101, P151
  14. Mallon PWG, 2007, CURR OPIN HIV AIDS, V2, P282, DOI 10.1097/COH.0b013e3281e72ca0
  15. Martin-Carbonero L, 2004, CLIN INFECT DIS, V38, P128
  16. Martinez-Sierra C, 2003, CLIN INFECT DIS, V36, P491
  17. Matsutani S, 1987, PORTAL HYPERTENSION, P197
  18. Meier JM, 2007, SEMIN NUCL MED, V37, P154, DOI 10.1053/j.semnuclmed.2007.02.001
  19. Mendes-Correa MCJ, 2005, AM J TROP MED HYG, V72, P762
  20. Monto A, 2006, AM J GASTROENTEROL, V101, P1509, DOI 10.1111/j.1572-0241.2006.00613.x
  21. Neau D, 2007, JAIDS-J ACQ IMM DEF, V45, P168, DOI 10.1097/QAI.0b013e318042e1db
  22. Palmentieri B, 2006, DIGEST LIVER DIS, V38, P485, DOI 10.1016/j.dld.2006.03.021
  23. PIETRI H, 1988, J ULTRAS MED, V7, P189
  24. Richard P, 1985, J Radiol, V66, P503
  25. SAPIRA JD, 1979, ARCH INTERN MED, V139, P971, DOI 10.1001/archinte.139.9.971
  26. Serfaty L, 1997, HEPATOLOGY, V26, P776, DOI 10.1002/hep.510260334
  27. Simonovsky V, 1999, BRIT J RADIOL, V72, P29
  28. Soriano V, 2007, AIDS, V21, P1073, DOI 10.1097/QAD.0b013e3281084e4d
  29. Lizardi-Cervera Javier, 2005, Ann Hepatol, V4, P188
  30. Sulkowsky MS, 2000, CLIN INFECT DIS S, V30, P77
  31. Tien Phyllis C, 2002, Semin Gastrointest Dis, V13, P47
  32. Tshibwabwa ET, 2000, ABDOM IMAGING, V25, P290, DOI 10.1007/s002610000035
  33. Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
  34. ZOLI M, 1995, AM J GASTROENTEROL, V90, P1428

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/46
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