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https://observatorio.fm.usp.br/handle/OPI/19948
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | NOVAK, Glaucia V. | - |
dc.contributor.author | MARQUES, Mariana | - |
dc.contributor.author | BALBI, Verena | - |
dc.contributor.author | GORMEZANO, Natali W. S. | - |
dc.contributor.author | KOZU, Katia | - |
dc.contributor.author | SAKAMOTO, Ana P. | - |
dc.contributor.author | PEREIRA, Rosa M. R. | - |
dc.contributor.author | TERRERI, Maria T. | - |
dc.contributor.author | MAGALHAES, Claudia S. | - |
dc.contributor.author | GUARIENTO, Andressa | - |
dc.contributor.author | SALLUM, Adriana M. E. | - |
dc.contributor.author | MARINI, Roberto | - |
dc.contributor.author | FERRIANI, Virginia Paes Leme | - |
dc.contributor.author | BARBOSA, Cassia Maria | - |
dc.contributor.author | CASTRO, Tania Caroline Monteiro de | - |
dc.contributor.author | RAMOS, Valeria C. | - |
dc.contributor.author | BONFA, Eloisa | - |
dc.contributor.author | SILVA, Clovis A. | - |
dc.date.accessioned | 2017-06-09T15:18:21Z | - |
dc.date.available | 2017-06-09T15:18:21Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | AUTOIMMUNITY REVIEWS, v.16, n.2, p.132-135, 2017 | - |
dc.identifier.issn | 1568-9972 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/19948 | - |
dc.description.abstract | Background: To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients. Methods: This was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, Sao Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients. Results: Anti-Ro/SSA and anti-La/SSB antibodies were evidenced in 209/645 (32%) and 102/645 (16%) of cSLE patients, respectively. Analysis of cSLE patients with and without anti-Ro/SSA antibodies revealed higher frequencies of malar rash (79% vs. 71%, p = 0.032), photosensitivity (73% vs. 65%, p = 0.035), cutaneous vasculitis (43% vs. 35%, p = 0.046) and musculoskeletal involvement (82% vs. 75%, p = 0.046) in spite of long and comparable disease duration in both groups (4.25 vs. 4.58 years, p = 0.973). Secondary Sjogren syndrome was observed in only five patients with this antibody (2.5% vs. 0%, p = 0.0035), two of them with concomitant anti-La/SSB. The presence of associated autoantibodies: anti-Sm (50% vs. 30%, p < 0.0001), anti-RNP (39% vs. 21%, p < 0.0001) and anti-ribossomal P protein (46% vs. 21%, p = 0.002) was also significantly higher in patients with anti-Ro/SAA antibodies. Further evaluation of cSLE patients with the presence of anti-La/SSB antibodies compared to those without these autoantibodies showed that the frequency of alopecia (70% vs. 51%, p = 0.0005), anti-Sm (59% vs. 31%, p < 0.0001) and anti-RNP (42% vs. 23%, p < 0.0001) were significantly higher in the former group. Conclusions: Our large multicenter cohort study provided novel evidence in cSLE that anti-Ro/SSA and/or anti-La/SSB antibodies were associated with mild manifestations, particularly cutaneous and musculoskeletal. Secondary Sjogren syndrome was rarely observed in these patients, in spite of comparable frequencies of anti-Ro/SSA and/or anti-La/SSB reported for adult SLE. | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 301805/2013-0, 303752/2015-7, 301479/2015-1, 305068/2014-8, 303422/2015-7] | - |
dc.description.sponsorship | Federico Foundation | - |
dc.description.sponsorship | Nucleo de Apoio a Pesquisa ""Sande da Crianca e do Adolescente"" da USP (NAP-CriAd) | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.ispartof | Autoimmunity Reviews | - |
dc.rights | restrictedAccess | - |
dc.subject | Anti-Ro/SSA autoantibodies | - |
dc.subject | Anti-La/SSB autoantibodies | - |
dc.subject | Sjogren syndrome and childhood-systemic | - |
dc.subject | lupus erythematosus | - |
dc.subject | Multicenter cohort | - |
dc.subject.other | cluster-analysis | - |
dc.subject.other | autoantibodies | - |
dc.subject.other | classification | - |
dc.subject.other | criteria | - |
dc.subject.other | disease | - |
dc.title | Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus | - |
dc.type | article | - |
dc.rights.holder | Copyright ELSEVIER SCIENCE BV | - |
dc.identifier.doi | 10.1016/j.autrev.2016.12.004 | - |
dc.identifier.pmid | 27988434 | - |
dc.subject.wos | Immunology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SAKAMOTO, Ana P.:Univ Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil | - |
hcfmusp.author.external | TERRERI, Maria T.:Univ Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil | - |
hcfmusp.author.external | MAGALHAES, Claudia S.:Sao Paulo State Univ, UNESP, Div Pediat Rheumatol, Fac Med Botucatu, Sao Paulo, SP, Brazil | - |
hcfmusp.author.external | GUARIENTO, Andressa:Innandade Santa Casa de Misericordia Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil | - |
hcfmusp.author.external | MARINI, Roberto:Univ Estadual Campinas, UNICAMP, Pediat Rheumatol Unit, Campinas, SP, Brazil | - |
hcfmusp.author.external | FERRIANI, Virginia Paes Leme:Univ Sao Paulo, Ribeirao Preto Med Sch, Pediat Rheumatol Unit, BR-05508 Sao Paulo, Brazil | - |
hcfmusp.author.external | BARBOSA, Cassia Maria:Hosp Infantil Darcy Vargas, Pediat Rheumatol Unit, Sao Paulo, Brazil | - |
hcfmusp.author.external | CASTRO, Tania Caroline Monteiro de:Hosp Menino Jesus, Pediat Rheumatol Unit, Sao Paulo, Brazil | - |
hcfmusp.author.external | RAMOS, Valeria C.:Pontifical Catholic Univ Sorocaba, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 132 | - |
hcfmusp.description.endpage | 135 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 16 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000394079900004 | - |
hcfmusp.origem.id | 2-s2.0-85009291543 | - |
hcfmusp.publisher.city | AMSTERDAM | - |
hcfmusp.publisher.country | NETHERLANDS | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1873-0183 | - |
hcfmusp.citation.scopus | 34 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MPE Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/36 |
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