Non-HDL cholesterol is a good predictor of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population

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art_ALVIM_NonHDL_cholesterol_is_a_good_predictor_of_the_2017.PDF (180.25 KB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2017
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
ALVIM, Rafael de Oliveira
MOURAO-JUNIOR, Carlos Alberto
MAGALHAES, Gessica Lopes
OLIVEIRA, Camila Maciel de
MILL, Jose Geraldo
Citação
CLINICS, v.72, n.2, p.106-110, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: Increased arterial stiffness is an important determinant of the risk of cardiovascular disease. Lipid profile impairment, especially hypercholesterolemia, is associated with stiffer blood vessels. Thus, the aim of this study was to determine which of the five circulating lipid components (high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL), total cholesterol (TC) and triglycerides) is the best predictor of increased arterial stiffness in an urban Brazilian population. METHODS: A random sample of 1,662 individuals from the general population of Vitoria, Brazil (25-64 years), was selected, and lipid components were measured using standard methods. Pulse wave velocity was measured using a non-invasive automatic device, and increased arterial stiffness was defined as a pulse wave velocity >= 10 m/s. RESULTS: In men, only total cholesterol (OR = 1.59; CI = 1.02 to 2.48, p = 0.04) was associated with the risk of increased arterial stiffness. In women, HDL-C (OR= 1.99; CI=1.18 to 3.35, p=0.01) and non-HDL-C (OR= 1.61; CI=1.01 to 2.56, p=0.04) were good predictors of the risk of increased arterial stiffness. However, these associations were only found in postmenopausal women (OR= 2.06; CI=1.00 to 4.26, p=0.05 for HDL-C and OR= 1.83; CI= 1.01 to 3.33, p= 0.04 for non-HDL-C). CONCLUSION: Our findings indicate that both HDL-C and non-HDL-C are good predictors of the risk of increased arterial stiffness in postmenopausal women in an urban Brazilian population and may be useful tools for assessing the risk of arterial stiffness.
Palavras-chave
Non-HDL-C, Arterial Stiffness, Dyslipidemia, Menopause
URI
https://observatorio.fm.usp.br/handle/OPI/20000
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/03