Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals

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art_NUNES_Alpha2Aadrenergic_receptor_and_eNOS_genetic_polymorphisms_are_associated_2016.PDF (251.04 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER IRELAND LTD
Autores
BARROSO, Lucia Pereira
RONDON, Maria Urbana Pinto Brandao
Citação
IJC HEART & VASCULATURE, v.13, p.14-18, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose: Muscle vasodilatation during exercise has been associated with cardiovascular health and may be influenced by genetic variability. The purpose of this study was to evaluate functional genetic polymorphisms of physiologic pathways related to the regulation of the cardiovascular function (alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor) and exercise muscle vasodilatation in apparently healthymen and women. Methods: We enrolled 689 individuals without established cardiovascular disease that had attended a check-up program. The vasodilatation was studied with venous occlusion plethysmography and determined by the increase of vascular conductance during handgrip exercise. Genotypes for ADRA1A Arg347Cys (rs1048101), ADRA2A 1780 C > T (rs553668), ADRA2B Del 301-303 (rs28365031), eNOS 786 T > C (rs2070744), eNOS Glu298Asp (rs1799983) and BDKRB2 (rs5810761) polymorphisms were assessed by polymerase chain reaction followed by high resolution melting analysis. Results: The eNOS rs2070744 polymorphism was significantly associated with forearm vascular conductance during exercise in women. Women with CC genotype showed higher vasodilatation than carriers of TC and TT genotypes (p=0.043). The ADRA2A rs553668 polymorphism was significantly associated with forearm vascular conductance during exercise inmen. Men with TT genotype had higher vasodilatation than carriers of CT and CC genotypes (p=0.025). Conclusions: eNOS rs207074 polymorphism in women and ADRA2A rs553668 polymorphism in men were associated with the increase of forearm vascular conductance during handgrip exercise. These findings suggest that eNOS and ADRA2A genetic polymorphisms may be potential markers of exercise muscle vasodilatation. (C) 2016 The Authors.
Palavras-chave
Muscle vasodilatation, Forearm vascular conductance, Exercise, Genetic polymorphism, Alpha-adrenergic receptor, Endothelial nitric oxide synthase, Bradykinin B2 receptor, Cardiovascular genetics
URI
https://observatorio.fm.usp.br/handle/OPI/20004
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/03