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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | LIMA, Josenilson F. | - |
dc.contributor.author | OLIVEIRA, Luanda M. S. | - |
dc.contributor.author | PEREIRA, Natalli Z. | - |
dc.contributor.author | DUARTE, Alberto J. S. | - |
dc.contributor.author | SATO, Maria N. | - |
dc.date.accessioned | 2017-06-09T15:37:40Z | - |
dc.date.available | 2017-06-09T15:37:40Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.7, article ID 524, 9p, 2017 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/20182 | - |
dc.description.abstract | Natural killer (NK) cells are the main mediator of the cytotoxic response in innate immunity and may be involved in resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Toll-like receptor (TLR) signalling is crucial for NK cell activation. Here, we investigated the polyfunctional NK cell response to TLR3 activation in serodiscordant couples. ESN subjects showed increased IFN-gamma. and CD107a expression in both NK subsets, CD56(bright) and CD56(dim) cells, in response to stimulation with a TLR3 agonist, while expression was impaired in the HIV-1-infected partners. TLR3-induced expression of IFN-gamma, TNF and CD107a by polyfunctional CD56bright NK cells was more pronounced in ESN individuals than that in healthy controls. Activated NK cells, as determined by CD38 expression, were increased only in the HIV-1-infected partners, with reduced IFN-gamma. and CD107a expression. Moreover, CD38(+) NK cells of the HIV-1-infected partners were associated with increased expression of inhibitory molecules, such as NKG2A, PD- 1 and Tim-3, while NK cells from ESN subjects showed decreased NKG2A expression. Altogether, these findings indicate that NK cells of ESN individuals were highly responsive to TLR3 activation and had a polyfunctional NK cell phenotype, while the impaired TLR3 response in HIV-1-infected partners was associated with an inhibitory/ exhaustion NK cell phenotype. | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2015/00263-7] | - |
dc.description.sponsorship | Laboratorio de Investigacao Medica, Unidade 56 do Hospital das Clinicas da Faculdade de Medicina de Sao Paulo | - |
dc.language.iso | eng | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | openAccess | - |
dc.subject.other | exposed uninfected individuals | - |
dc.subject.other | hiv-1 infection | - |
dc.subject.other | t-cells | - |
dc.subject.other | integrin alpha(4)beta(7) | - |
dc.subject.other | antiretroviral therapy | - |
dc.subject.other | immune activation | - |
dc.subject.other | nk cells | - |
dc.subject.other | expression | - |
dc.subject.other | resistance | - |
dc.subject.other | level | - |
dc.title | Polyfunctional natural killer cells with a low activation profile in response to Toll-like receptor 3 activation in HIV-1-exposed seronegative subjects | - |
dc.type | article | - |
dc.rights.holder | Copyright NATURE PUBLISHING GROUP | - |
dc.identifier.doi | 10.1038/s41598-017-00637-3 | - |
dc.identifier.pmid | 28373665 | - |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.articlenumber | 524 | - |
hcfmusp.description.volume | 7 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-85017118586 | - |
hcfmusp.origem.id | WOS:000398134800001 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
hcfmusp.relation.reference | Arthos J, 2008, NAT IMMUNOL, V9, P301, DOI 10.1038/ni1566 | - |
hcfmusp.relation.reference | Aujla SJ, 2009, J MOL MED-JMM, V87, P451, DOI 10.1007/s00109-009-0448-1 | - |
hcfmusp.relation.reference | Begaud E, 2006, RETROVIROLOGY, V3, DOI 10.1186/1742-4690-3-35 | - |
hcfmusp.relation.reference | Benito JM, 2004, AIDS RES HUM RETROV, V20, P227 | - |
hcfmusp.relation.reference | Betts MR, 2006, BLOOD, V107, P4781, DOI 10.1182/blood-2005-12-4818 | - |
hcfmusp.relation.reference | Bixler S. L., 2013, CLIN DEV IMMUNOL, V2013, DOI 10.1155/2013/852418 | - |
hcfmusp.relation.reference | Brandt L, 2013, JAIDS-J ACQ IMM DEF, V63, P418, DOI 10.1097/QAI.0b013e31828fa22b | - |
hcfmusp.relation.reference | Brenchley JM, 2008, BLOOD, V112, P2826, DOI 10.1182/blood-2008-05-159301 | - |
hcfmusp.relation.reference | Carrillo J, 2013, AIDS, V27, P1375, DOI 10.1097/QAD.0b013e32835fac08 | - |
hcfmusp.relation.reference | Cicala C, 2009, P NATL ACAD SCI USA, V106, P20877, DOI 10.1073/pnas.0911796106 | - |
hcfmusp.relation.reference | Clerici M, 2002, AIDS, V16, P1731, DOI 10.1097/00002030-200209060-00004 | - |
hcfmusp.relation.reference | Deeks SG, 2004, BLOOD, V104, P942, DOI 10.1182/blood-2003-09-3333 | - |
hcfmusp.relation.reference | Dunkle KL, 2008, LANCET, V371, P2183, DOI 10.1016/S0140-6736(08)60953-8 | - |
hcfmusp.relation.reference | Erickson AL, 2008, CLIN VACCINE IMMUNOL, V15, P1745, DOI 10.1128/CVI.00247-08 | - |
hcfmusp.relation.reference | Ferre AL, 2009, BLOOD, V113, P3978, DOI 10.1182/blood-2008-10-182709 | - |
hcfmusp.relation.reference | Giorgi JV, 2002, J ACQ IMMUN DEF SYND, V29, P346 | - |
hcfmusp.relation.reference | HO M, 1990, REV INFECT DIS, V12, pS701 | - |
hcfmusp.relation.reference | Horton RE, 2010, J INFECT DIS, V202, pS377, DOI 10.1086/655971 | - |
hcfmusp.relation.reference | Hua S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101920 | - |
hcfmusp.relation.reference | Johansson-Lindbom B, 2007, IMMUNOL REV, V215, P226, DOI 10.1111/j.1600-065X.2006.00482.x | - |
hcfmusp.relation.reference | Kim CJ, 2013, J IMMUNOL, V191, P2164, DOI 10.4049/jimmunol.1300829 | - |
hcfmusp.relation.reference | Koning FA, 2005, J IMMUNOL, V175, P6117 | - |
hcfmusp.relation.reference | Lederman MM, 2010, J INFECT DIS, V202, pS333, DOI 10.1086/655967 | - |
hcfmusp.relation.reference | Lee J, 2011, MOL CELL BIOL, V31, P3963, DOI 10.1128/MCB.05297-11 | - |
hcfmusp.relation.reference | Liang SC, 2006, J EXP MED, V203, P2271, DOI 10.1084/jem.20061308 | - |
hcfmusp.relation.reference | Liu R, 1996, CELL, V86, P367, DOI 10.1016/S0092-8674(00)80110-5 | - |
hcfmusp.relation.reference | Liu Y, 2011, IMMUNOLOGY, V132, P540, DOI 10.1111/j.1365-2567.2010.03399.x | - |
hcfmusp.relation.reference | McLaren PJ, 2010, J INFECT DIS, V202, pS339, DOI 10.1086/655968 | - |
hcfmusp.relation.reference | Murashev BV, 2012, AIDS RES HUM RETROV, V28, P1598, DOI [10.1089/AID.2011.0335, 10.1089/aid.2011.0335] | - |
hcfmusp.relation.reference | Ndhlovu LC, 2012, BLOOD, V119, P3734, DOI 10.1182/blood-2011-11-392951 | - |
hcfmusp.relation.reference | Pancino G, 2010, J INFECT DIS, V202, pS345, DOI 10.1086/655973 | - |
hcfmusp.relation.reference | Pera A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088538 | - |
hcfmusp.relation.reference | Ravet S, 2007, BLOOD, V109, P4296, DOI 10.1182/blood-2006-08-040238 | - |
hcfmusp.relation.reference | Schmidt KN, 2004, J IMMUNOL, V172, P138 | - |
hcfmusp.relation.reference | Shearer G, 2010, J INFECT DIS, V202, pS329, DOI 10.1086/655974 | - |
hcfmusp.relation.reference | Sironi M, 2012, J IMMUNOL, V188, P818, DOI 10.4049/jimmunol.1102179 | - |
hcfmusp.relation.reference | Taborda NA, 2015, AIDS RES HUM RETROV, V31, P636, DOI [10.1089/AID.2014.0325, 10.1089/aid.2014.0325] | - |
hcfmusp.relation.reference | Trifari S, 2009, NAT IMMUNOL, V10, P864, DOI 10.1038/ni.1770 | - |
hcfmusp.relation.reference | UNAIDS, 2013, GLOB REP GLOB AIDS E | - |
hcfmusp.relation.reference | Van Braeckel E, 2013, VACCINE, V31, P3739, DOI 10.1016/j.vaccine.2013.05.021 | - |
hcfmusp.relation.reference | van de Weyer Philipp S, 2006, Biochem Biophys Res Commun, V351, P571, DOI 10.1016/j.bbrc.2006.10.079 | - |
hcfmusp.relation.reference | Zhang RJ, 2007, AIDS, V21, pS9, DOI 10.1097/01.aids.0000304691.32014.19 | - |
hcfmusp.relation.reference | Zhu C, 2005, NAT IMMUNOL, V6, P1245, DOI 10.1038/ni1271 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 20 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDT Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/56 Artigos e Materiais de Revistas Científicas - ODS/03 |
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