Effects of antidepressant and treadmill gait training on recovery from spinal cord injury in rats
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Citações na Scopus
17
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
Citação
SPINAL CORD, v.51, n.6, p.501-507, 2013
Resumo
Study design: Experimental, controlled, animal study. Objectives: To evaluate the influences of antidepressant treatment, treadmill gait training and a combination of these therapies in rats with experimental, acute spinal cord injury (SCI). Setting: Brazil. Methods: 48 Wistar rats were given standardized SCI; rats were then randomly assigned to four treatment groups: (1) motor rehabilitation therapy for 1 hour daily (gait training); (2) daily treatment with the antidepressant, fluoxetine (0.3 ml per 100 g intraperitoneally), beginning 24 h after the trauma; (3) combined fluoxetine treatment and gait training, or (4) untreated (controls). Neurological recovery was tested with the Basso, Beattie and Bresnahan (BBB) scale at 2, 7, 14, 21, 28,35 and 42 days after injury. Moreover, on day 42, all rats underwent a motor-evoked potential test (MEP); then, after euthanasia, histopathological evaluation was conducted in the area of SCI. Results: Based on the BBB scale, the combined treatment group showed significantly greater improvement compared with the other three groups, from the 14th to the 42nd day of observation. The MEP revealed that all treated groups showed significant improvement compared with the control group (P<0.02 for latency and P<0.01 for amplitude). Conclusion: Our results indicated that a combination of antidepressant and treadmill gait training was superior to either treatment alone for improving functional deficits in rats with experimental, acute SCI.
Palavras-chave
spinal cord injuries, central nervous system, injuries, rats
Referências
- Agrawal G, 2010, SPINE, V35, P1122, DOI 10.1097/BRS.0b013e3181be5fa7
- BASSO DM, 1995, J NEUROTRAUM, V12, P1, DOI 10.1089/neu.1995.12.1
- Basso DM, 1996, J NEUROTRAUM, V13, P343, DOI 10.1089/neu.1996.13.343
- Bertelli JA, 2004, J NEUROSCI METH, V134, P75, DOI 10.1016/j.jneumeth.2003.11.002
- Bharne AP, 2011, NEUROPEPTIDES, V45, P25, DOI 10.1016/j.npep.2010.10.001
- Blight A R, 2001, Curr Opin Investig Drugs, V2, P801
- Chopek JW, 2010, MECH AGEING DEV, V131, P650, DOI [10.1016/j.mad.2010.09.001, 10.1016/j.mad.2010.08.001]
- Cristante AF, 2009, SPINAL CORD, V47, P458, DOI 10.1038/sc.2008.155
- Cristante AF, 2012, SPINAL CORD, V50, P502, DOI 10.1038/sc.2012.16
- Engesser-Cesar C, 2007, NEUROSCIENCE, V144, P1033, DOI 10.1016/j.neuroscience.2006.10.016
- Ferguson AR, 2004, J NEUROTRAUM, V21, P1601, DOI 10.1089/0897715042441747
- Ferreira AFB, 2010, BRAIN RES, V1361, P31, DOI 10.1016/j.brainres.2010.09.045
- Ferreira Ricardo, 2005, Acta ortop. bras., V13, P112
- Foret A, 2010, J NEUROCHEM, V112, P762, DOI 10.1111/j.1471-4159.2009.06500.x
- Fouad K, 2010, J NEUROPHYSIOL, V104, P2975, DOI 10.1152/jn.00499.2010
- Gerin CG, 2010, SYNAPSE, V64, P855, DOI 10.1002/syn.20802
- Grossman RG, 2001, NEUROSURGERY, V49, P580, DOI 10.1097/00006123-200109000-00008
- Hayashi Y, 2010, EXP NEUROL, V221, P68, DOI 10.1016/j.expneurol.2009.10.003
- Holschneider D P, 2007, Brain Res, V1184, P96, DOI 10.1016/j.brainres.2007.09.081
- Ichiyama RM, 2008, NEUROSCI LETT, V438, P281, DOI 10.1016/j.neulet.2008.04.080
- Kao T, 2006, BRAIN RES, V1112, P159, DOI 10.1016/j.brainres.2006.07.020
- Kemp BJ, 2004, J SPINAL CORD MED, V27, P22
- Liu M, 2008, SPINAL CORD, V46, P488, DOI 10.1038/sj.sc.3102169
- Marcon RM, 2010, SPINAL CORD, V48, P808, DOI 10.1038/sc.2010.37
- Metz GAS, 2000, BRAIN RES, V883, P165, DOI 10.1016/S0006-8993(00)02778-5
- Moyses ZP, 2008, NEPHROL DIAL TRANSPL, V23, P1173, DOI 10.1093/ndt/gfm714
- Petruska JC, 2007, J NEUROSCI, V27, P4460, DOI 10.1523/JNEUROSCI.2302-06.2007
- Santos GB, 2011, ACTA ORTOP BRAS, V19, P87
- Schwab ME, 1996, PHYSIOL REV, V76, P319
- Souza FI, 2011, COLUNA COLUMNA, V10, P305
- Ung RV, 2008, EUR J NEUROSCI, V28, P2231, DOI 10.1111/j.1460-9568.2008.06508.x
- van Middendorp JJ, 2012, SPINAL CORD, V50, P686, DOI 10.1038/sc.2012.34
- Yang ML, 2012, SPINAL CORD, V50, P141, DOI 10.1038/sc.2011.126