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https://observatorio.fm.usp.br/handle/OPI/21217
Title: | Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism |
Authors: | AMATO, Lorena Guimaraes Lima; LATRONICO, Ana Claudia; SILVEIRA, Leticia Ferreira Gontijo |
Citation: | ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, v.46, n.2, p.283-303, 2017 |
Abstract: | Congenital isolated hypogonadotropic hypogonadism (IHH) is a clinically and genetically heterogenous disorder characterized by abnormal synthesis, secretion, or action of gonadotropin-releasing hormone, a key hypothalamic decapeptide that orchestrates the reproductive axis. Several modes of inheritance have been identified. A growing list of causative genes has been implicated in the molecular pathogenesis of syndromic and nonsyndromic IHH, largely contributing for better understanding the complex neuroendocrine control of reproduction. This article summarizes the great advances of molecular genetics of IHH and pointed up the heterogeneity and complexity of the genetic basis of this condition. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/42 |
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