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https://observatorio.fm.usp.br/handle/OPI/21283
Title: | Comparison of anal HPV natural history among men by country of residence: Brazil, Mexico, and the United States |
Authors: | SUDENGA, Staci L.; NYITRAY, Alan G.; TORRES, B. Nelson; SILVA, Roberto; VILLA, Luisa; LAZCANO-PONCE, Eduardo; ABRAHAMSEN, Martha; BAGGIO, Maria Luiza; SALMERON, Jorge; QUITERIO, Manuel; GIULIANO, Anna R. |
Citation: | JOURNAL OF INFECTION, v.75, n.1, p.35-47, 2017 |
Abstract: | Objectives: Globally, anal cancer incidence is rare, but is increasing in some world regions. Our objective was to assess differences in anal HPV natural history in three countries. Methods: Men aged 18-70 years were recruited from the US (n = 634), Mexico (n = 665), and Brazil (n = 731). Anal specimens were collected every six-months. HPV genotyping was assessed by Linear Array. Anal HPV prevalence was compared using the Fisher's exact test. HPV infection incidence rates (IR) and 95% confidence intervals (CI) were calculated. Results: Any anal HPV prevalence was highest among men from Brazil (24%) compared to Mexico (15%) and the US (15%). When stratified by sexual history, the prevalence of any HPV among MSM/MSMW was 43%, 37%, and 45% and 9%, 12%, and 10% for MSW from Brazil, Mexico, and US, respectively. Any HPV incidence was significantly higher among men from Brazil compared to US men (IRR = 2.4, 95% CI = 1.7-3.4) and comparable between men from Mexico and the US (IRR = 1.2, 95% CI = 0.8-1.8). Conclusion: Men in Brazil and Mexico often have similar, if not higher incidence of anal HPV compared to men from the U.S., and may benefit from gender neutral HPV vaccine policies. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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