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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BENRICK, Anna | - |
dc.contributor.author | KOKOSAR, Milana | - |
dc.contributor.author | HU, Min | - |
dc.contributor.author | LARSSON, Martin | - |
dc.contributor.author | MALIQUEO, Manuel | - |
dc.contributor.author | MARCONDES, Rodrigo Rodrigues | - |
dc.contributor.author | SOLIGO, Marzia | - |
dc.contributor.author | PROTTO, Virginia | - |
dc.contributor.author | JERLHAG, Elisabet | - |
dc.contributor.author | SAZONOVA, Antonina | - |
dc.contributor.author | BEHRE, Carl Johan | - |
dc.contributor.author | HOJLUND, Kurt | - |
dc.contributor.author | THOREN, Peter | - |
dc.contributor.author | STENER-VICTORIN, Elisabet | - |
dc.date.accessioned | 2017-08-17T19:20:43Z | - |
dc.date.available | 2017-08-17T19:20:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | FASEB JOURNAL, v.31, n.8, p.3288-3297, 2017 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/21453 | - |
dc.description.abstract | A single bout of low-frequency electroacupuncture (EA) causing muscle contractions increases whole-body glucose uptake in insulin-resistant rats. We explored the underlying mechanism of this finding and whether it can be translated into clinical settings. Changes in glucose infusion rate (GIR) were measured by euglycemic-hyperinsulinemic clamp during and after 45 min of low-frequency EA in 21 overweight/obese women with polycystic ovary syndrome (PCOS) and 21 controls matched for age, weight, and body mass index (experiment 1) and in rats receiving autonomic receptor blockers (experiment 2). GIR was higher after EA in controls and women with PCOS. Plasma serotonin levels and homovanillic acid, markers of vagal activity, decreased in both controls and patients with PCOS. Adipose tissue expression of pro-nerve growth factor (proNGF) decreased, and the mature NGF/proNGF ratio increased after EA in PCOS, but not in controls, suggesting increased sympathetic-driven adipose tissue metabolism. Administration of alpha-/beta-adrenergic receptor blockers in rats blocked the increase in GIR in response to EA. Muscarinic and dopamine receptor antagonist also blocked the response but with slower onset. In conclusion, a single bout of EA increases whole-body glucose uptake by activation of the sympathetic and partly the parasympathetic nervous systems, which could have important clinical implications for the treatment of insulin resistance. | - |
dc.description.sponsorship | Swedish Medical Research Council [2014-2775] | - |
dc.description.sponsorship | Jane and Dan Ohlsson Foundation | - |
dc.description.sponsorship | Wilhelm and Martina Lundgrens's Science Fund | - |
dc.description.sponsorship | Hjalmar Svensson Foundation | - |
dc.description.sponsorship | Adlerbert Research Foundation | - |
dc.description.sponsorship | Novo Nordisk Foundation [NNF16OC0020744] | - |
dc.description.sponsorship | Strategic Research Programme in Diabetes at Karolinska Institutet | - |
dc.description.sponsorship | Royal Society of Arts and Sciences in Gothenburg | - |
dc.description.sponsorship | Swedish federal government under the LUA/ALF [ALFGBG-429501] | - |
dc.description.sponsorship | Stockholm County Council | - |
dc.description.sponsorship | Karolinska Institutet | - |
dc.description.sponsorship | Becas Chile Programme | - |
dc.description.sponsorship | University of Chile | - |
dc.description.sponsorship | Italian National Research Council (CNR) | - |
dc.language.iso | eng | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.relation.ispartof | Faseb Journal | - |
dc.rights | restrictedAccess | - |
dc.subject | glucose homeostasis | - |
dc.subject | polycystic ovary syndrome | - |
dc.subject | insulin resistance | - |
dc.subject | muscle contraction | - |
dc.subject.other | polycystic-ovary-syndrome | - |
dc.subject.other | blood-flow responses | - |
dc.subject.other | insulin sensitivity | - |
dc.subject.other | anesthetized rats | - |
dc.subject.other | growth-factor | - |
dc.subject.other | electrical-stimulation | - |
dc.subject.other | different frequencies | - |
dc.subject.other | diabetic-rats | - |
dc.subject.other | acupuncture | - |
dc.subject.other | resistance | - |
dc.title | Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture | - |
dc.type | article | - |
dc.rights.holder | Copyright FEDERATION AMER SOC EXP BIOL | - |
dc.identifier.doi | 10.1096/fj.201601381R | - |
dc.identifier.pmid | 28404742 | - |
dc.subject.wos | Biochemistry & Molecular Biology | - |
dc.subject.wos | Biology | - |
dc.subject.wos | Cell Biology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BENRICK, Anna:Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden; Univ Skovde, Sch Hlth & Educ, Skovde, Sweden | - |
hcfmusp.author.external | KOKOSAR, Milana:Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden | - |
hcfmusp.author.external | HU, Min:Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden | - |
hcfmusp.author.external | LARSSON, Martin:Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden | - |
hcfmusp.author.external | MALIQUEO, Manuel:Univ Chile, Endocrinol & Metab Lab, West Div, Sch Med, Santiago, Chile | - |
hcfmusp.author.external | SOLIGO, Marzia:CNR, Inst Translat Pharmacol, Rome, Italy | - |
hcfmusp.author.external | PROTTO, Virginia:CNR, Inst Translat Pharmacol, Rome, Italy | - |
hcfmusp.author.external | JERLHAG, Elisabet:Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Inst Neurosci & Physiol, Gothenburg, Sweden | - |
hcfmusp.author.external | SAZONOVA, Antonina:Univ Gothenburg, Sahlgrenska Acad, Dept Obstet & Gynecol, Inst Clin Sci, Gothenburg, Sweden | - |
hcfmusp.author.external | BEHRE, Carl Johan:Univ Gothenburg, Sahlgrenska Acad, Dept Cardiol, Inst Med, Gothenburg, Sweden | - |
hcfmusp.author.external | HOJLUND, Kurt:Odense Univ Hosp, Dept Endocrinol, Odense, Denmark | - |
hcfmusp.author.external | THOREN, Peter:Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden | - |
hcfmusp.author.external | STENER-VICTORIN, Elisabet:Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden | - |
hcfmusp.description.beginpage | 3288 | - |
hcfmusp.description.endpage | 3297 | - |
hcfmusp.description.issue | 8 | - |
hcfmusp.description.volume | 31 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-85026825921 | - |
hcfmusp.origem.id | WOS:000405932400009 | - |
hcfmusp.publisher.city | BETHESDA | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1530-6860 | - |
hcfmusp.citation.scopus | 33 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/58 Artigos e Materiais de Revistas Científicas - ODS/03 |
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