The role of titanium dioxide in the gut

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art_ACHTSCHIN_The_role_of_titanium_dioxide_in_the_gut_2017.PDF (173.93 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
EMERALD GROUP PUBLISHING LTD
Autores
ACHTSCHIN, Cassiana Ganem
Citação
NUTRITION & FOOD SCIENCE, v.47, n.3, p.432-442, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose -Titanium is a naturally occurring mineral in the form of titanium dioxide (TiO2) and is one of the most widely used food additives. The purpose of this review article is to show the importance of the accumulation of this mineral in the gut and its relation with inflammatory processes. Methodology - This is a literature review study from 2002 to 2016, focusing on studies with TiO2 and its relation with inflammatory bowel diseases. Findings -Articles describe that TiO2 is resistant to gastrointestinal degradation, as it has high stability, and that its particles, ingested daily, may bind to biomolecules in the lumen or be absorbed by the intestinal mucosa, accumulating in the macrophages of lymphoid tissue in the gut, thus causing or aggravating the inflammatory response in the inflamed bowel. Limitations/implications -There is a limited number of studies on the long-term impact of dietary microparticles in animal models, in healthy subjects and in patients with inflammatory bowel diseases. Practical implications -It is necessary to regulate the amount of TiO2 used in industrialized products. Social implications - The high consumption of processed foods, as opposed to a healthy diet based on the balanced consumption of nutrients, is relevant, as it may lead to or exacerbate intestinal inflammation. Originality/value - This review indicates that titanium particles may mediate toxicological processes leading to an abnormal increase in intestinal permeability, which may be particularly aggravating in patients with inflammatory bowel diseases.
Palavras-chave
Particles, Inflammation, Intestine, Titanium dioxide
URI
https://observatorio.fm.usp.br/handle/OPI/21586
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/07