Regulatory T-Cell Distribution within Lung Compartments in COPD

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Arquivos
art_SALES_Regulatory_TCell_Distribution_within_Lung_Compartments_in_COPD_2017.PDF (1.79 MB)
Citações na Scopus
29
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS INC
Autores
ZANCHETTA, Ivy A.
FERRAZ, Luiz Fernando S.
Citação
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v.14, n.5, p.533-542, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The importance of the adaptive immune response, specifically the role of regulatory T (Treg) cells in controlling the obstruction progression in smokers, has been highlighted. To quantify the adaptive immune cells in different lung compartments, we used lung tissues from 21 never-smokers without lung disease, 22 current and/or ex-smokers without lung disease (NOS) and 13 current and/or ex-smokers with chronic obstructive pulmonary disease (COPD) for histological analysis. We observed increased T, B, IL-17 and BAFF(+) cells in small and large airways of COPD individuals; however, in the NOS, we only observed increase in T and IL-17(+) cells only in small airways. A decrease in the density of Treg(+), TGF-beta(+) and IL-10(+) in small and large airways was observed only in COPD individuals. In the lymphoid tissues, Treg, T,B-cells and BAFF(+) cells were also increased in COPD; however, changes in Treg inhibitory associated cytokineswere not observed in this compartment. Therefore, our results suggest that difference in Treg(+) cell distributions in lung compartments and the decrease in TGF-beta(+) and IL-10(+) cells in the airways may lead to the obstruction in smokers.
Palavras-chave
Adaptive immunity, COPD, interleukin-10, T-cells, regulatory T-cells, TGF-beta
URI
https://observatorio.fm.usp.br/handle/OPI/22019
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/59
Artigos e Materiais de Revistas Científicas - ODS/03