Cell Transplantation for Spinal Cord Injury: A Systematic Review

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art_LEPSKI_Cell_Transplantation_for_Spinal_Cord_Injury_A_Systematic_2013.PDF (393.16 KB)
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127
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article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
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HINDAWI PUBLISHING CORPORATION
Autores
LI, Jun
Citação
BIOMED RESEARCH INTERNATIONAL, article ID 786475, 32p, 2013
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years. A number of different kinds of stem cells, neural progenitors, and glial cells have been tested in basic research, and most have been excluded from clinical studies because of a variety of reasons, including safety and efficacy.. e signaling pathways, protein interactions, cellular behavior, and the differentiated fates of experimental cells have been studied in vitro in detail. Furthermore, the survival, proliferation, differentiation, and effects on promoting functional recovery of transplanted cells have also been examined in different animal SCI models. However, despite significant progress, a ""bench to bedside"" gap still exists. In this paper, we comprehensively cover publications in the field from the last years. The most commonly utilized cell lineages were covered in this paper and specific areas covered include survival of grafted cells, axonal regeneration and remyelination, sensory and motor functional recovery, and electrophysiological improvements. Finally we also review the literature on the in vivo tracking techniques for transplanted cells.
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https://observatorio.fm.usp.br/handle/OPI/2240
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICESP