Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/22811
Title: | The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients |
Authors: | SCHREIBER, Roberto; FERREIRA-SAE, Maria C.; RONCHI, Juliana A.; PIO-MAGALHAES, Jose A.; CIPOLLI, Jose A.; MATOS-SOUZA, Jose R.; MILL, Jose G.; VERCESI, Anibal E.; KRIEGER, Jose E.; FRANCHINI, Kleber G.; PEREIRA, Alexandre C.; NADRUZ JUNIOR, Wilson |
Citation: | BMC MEDICAL GENETICS, v.12, article ID 114, 6p, 2011 |
Abstract: | Background: Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T polymorphism of the p22-phox gene (CYBA) on left ventricular structure in Brazilian hypertensive subjects. Methods: We cross-sectionally evaluated 561 patients from 2 independent centers [Campinas (n = 441) and Vitoria (n = 120)] by clinical history, physical examination, anthropometry, analysis of metabolic and echocardiography parameters as well as p22-phox C242T polymorphism genotyping. In addition, NADPH-oxidase activity was quantified in peripheral mononuclear cells from a subgroup of Campinas sample. Results: Genotype frequencies in both samples were consistent with the Hardy-Weinberg equilibrium. Subjects with the T allele presented higher left ventricular mass/height(2.7) than those carrying the CC genotype in Campinas (76.8 +/- 1.6 vs 70.9 +/- 1.4 g/m(2.7); p = 0.009), and in Vitoria (45.6 +/- 1.9 vs 39.9 +/- 1.4 g/m(2.7); p = 0.023) samples. These results were confirmed by stepwise regression analyses adjusted for age, gender, blood pressure, metabolic variables and use of anti-hypertensive medications. In addition, increased NADPH-oxidase activity was detected in peripheral mononuclear cells from T allele carriers compared with CC genotype carriers (p = 0.03). Conclusions: The T allele of the p22-phox C242T polymorphism is associated with higher left ventricular mass/height(2.7) and increased NADPH-oxidase activity in Brazilian hypertensive patients. These data suggest that genetic variation within NADPH-oxidase components may modulate left ventricular remodeling in subjects with systemic hypertension. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/13 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SCHREIBER_The_C242T_polymorphism_of_the_p22phox_gene_CYBA_2011.PDF | publishedVersion (English) | 297.77 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.