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https://observatorio.fm.usp.br/handle/OPI/22897
Title: | Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice |
Authors: | FARIA, Paulo Rogerio de; CHAMMAS, Roger; MELO, Thaissa Lopes de; HSU, Daniel K.; LIU, Fu-Tong; NONOGAKI, Suely; CARDOSO, Sergio Vitorino; LOYOLA, Adriano Mota |
Citation: | EXPERIMENTAL AND MOLECULAR PATHOLOGY, v.90, n.2, p.189-193, 2011 |
Abstract: | Background: Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. Aims: To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral carcinogenesis. Methods: Galectin-3-deficient (gal3(-/-)) and wild-type (gal3(+/+)) mice were challenged with 4-nitroquinoline-1-oxide in drinking water for 16 weeks and killed at different times. Tongues were removed and the number of dysplasias and carcinomas was counted. An immunohistochemical study for galectin-3 was performed only in the tongue from gal3(+/+) mice. Results: In both groups, a reduction of dysplasias and an increase of carcinomas from week 16 to week 32 (p > 0.05) were observed. A predominance of high cytoplasmic and nuclear galectin-3 expression was observed in carcinomas (64.7%) and dysplasias (55.5%), respectively (p > 0.05). The perilesional areas always presented a statistical cytoplasmic and nuclear galectin-3 overexpression. Conclusions: Absence of galectin-3 did not directly affect the process of carcinogenesis and a cytoplasm shift of galectin-3 seems to be associated with development of tongue carcinomas. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - LIM/24 |
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