Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/23199
Title: Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women
Authors: DEMETRIO, Frederico NavasRENNO JR., JoelGIANFALDONI, ArleteGONCALVES, MarceloHALBE, Hans WolfgangFILHO, Antonio Helio Guerra V.GORENSTEIN, Clarice
Citation: ARCHIVES OF WOMENS MENTAL HEALTH, v.14, n.6, p.479-486, 2011
Abstract: The efficacy of estrogen replacement therapy (ERT) for mood disturbances associated with menopause has yet to be firmly established. The objective of this study was to investigate the efficacy of ERT for improving mood and anxiety of non-depressive postmenopausal women. This double-blind, randomized, placebo-controlled study involved two treatment groups: one receiving conjugated equine estrogens (CEEs; 0.625 mg/day) and the other placebo, for six cycles of 28 days each. Subjects were hysterectomized, healthy, non-depressive (according to Schedule for Affective Disorders and Schizophrenia, Life Time Version [SADS-L]) women. Depressive and anxiety symptoms were assessed with the Beck Depression Inventory (BDI), and the Hamilton Anxiety Scale (HAMA), respectively. The Profile of Mood States (POMS) and other scales were used to characterize symptoms. In both groups, BDI scores were significantly lower at cycles 1, 2, 3, and 6, compared with baseline assessments (p < 0.01). Anxiety scores for both groups significantly improved from cycle 3 to study endpoint. The only significant difference favoring the active group occurred at cycle 1. POMS scores were significantly improved at the end of cycles 1, 2, 3 and 6 among treated subjects and at the end of cycles 2, 3, and 6 among placebo subjects. ERT is not associated with improvements in mood or anxiety symptoms in non-depressive, hysterectomized, postmenopausal women.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/IPq
Instituto de Psiquiatria - HC/IPq


Files in This Item:
File Description SizeFormat 
art_DEMETRIO_Effect_of_estrogen_replacement_therapy_on_symptoms_of_2011.PDF
  Restricted Access
publishedVersion (English)236.8 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.