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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | PATRIOTA, Regia Celli Ribeiro | - |
dc.contributor.author | RODRIGUES, Consuelo Junqueira | - |
dc.contributor.author | CUCE, Luiz Carlos | - |
dc.date.accessioned | 2017-11-27T16:33:06Z | - |
dc.date.available | 2017-11-27T16:33:06Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | ANAIS BRASILEIROS DE DERMATOLOGIA, v.86, n.6, p.1129-1133, 2011 | - |
dc.identifier.issn | 0365-0596 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/23262 | - |
dc.description.abstract | BACKGROUND: Intense pulsed light has been used in the treatment of photoaging without a full understanding of its mechanism of action. OBJECTIVE: To study the effect of intense pulsed light on photoaging and on the skin immune response by means of a clinical and histopathological study, evaluating Langerhans cells (CD1), expression of intercellular adhesion molecule, of CD4 and CD8 lymphocytes and quantification of collagen and elastic fibers. METHODS: In 2006 a total of 26 patients, aged 40 to 65 years, with phototypes II to III (Fitzpatrick scale), were treated for photoaging using intense pulsed light in five sessions with a monthly interval. All the patients were subjected to histological and immunohistochemical evaluation 6 months after treatment. RESULTS: At the end of the treatment clinical improvement was observed in 76.92% of cases. This improvement was associated to a significant increase of collagen (51.33%) and elastic (44.13%) fibers. Intense pulsed light treatment led to a reduction of CD4 lymphocytes and did not alter the amount of CD8 lymphocytes. It also led to a significant increase of small, nonectatic blood vessels, positive intercellular adhesion molecule. CONCLUSION: Facial treatment with intense pulsed light promoted major clinical improvement that was confirmed by histological examination of the skin. This technique is a good treatment option for skin photoaging because it is non-ablative, safe and effective. | - |
dc.description.abstract | FUNDAMENTOS: A luz intensa pulsada tem sido muito utilizada no tratamento do fotoenvelhecimento sem completo conhecimento de seu mecanismo de ação. OBJETIVO: Estudar a ação da luz intensa pulsada no fotoenvelhecimento e na resposta imunológica cutânea por meio de estudo clínico, histopatológico, avaliando células de Langerhans (CD1), expressão da molécula de adesão intercelular, de linfócitos CD4 e CD8 e quantificação de colágeno e fibras elásticas. MÉTODOS: Um total de 26 pacientes, com idades entre 40 e 65 anos, com fototipos II a III de Fitzpatrick, foram tratadas do fotoenvelhecimento usando LIP, em 5 sessões, com intervalo mensal, durante o ano de 2006. Todas as pacientes foram submetidas à avaliação histológica e imuno-histoquímica 6 meses após o tratamento. RESULTADOS: Ao término do tratamento, houve melhora clínica em 76,92% dos casos, estando relacionada ao aumento significante de fibras colágenas (51,33%) e elásticas (44,13%). O tratamento com luz intensa pulsada promoveu redução de linfócitos CD4 e não alterou a intensidade de linfócitos CD8. Além disso, promoveu aumento significante de pequenos vasos sanguíneos, não ectásicos, molécula de adesão intercelular positivos. CONCLUSÃO: O tratamento facial com luz intensa pulsada promoveu intensa melhora clínica que foi comprovada pelo estudo histopatológico da pele, constituindo boa opção de tratamento para o fotoenvelhecimento cutâneo, por ser técnica não- ablativa, segura e eficaz | - |
dc.language.iso | por | - |
dc.language.iso | eng | - |
dc.publisher | SOC BRASILEIRA DERMATOLOGIA | - |
dc.relation.ispartof | Anais Brasileiros de Dermatologia | - |
dc.rights | openAccess | - |
dc.subject | Collagen | - |
dc.subject | Elastic tissue | - |
dc.subject | Lasers | - |
dc.subject | Skin aging | - |
dc.subject | Rejuvenation | - |
dc.subject | Colágeno | - |
dc.subject | Envelhecimento da pele | - |
dc.subject | Lasers | - |
dc.subject | Rejuvenescimento | - |
dc.subject | Tecido elástico | - |
dc.subject.other | nd-yag laser | - |
dc.subject.other | histologic evaluation | - |
dc.subject.other | nonablative treatment | - |
dc.subject.other | skin rejuvenation | - |
dc.subject.other | rhytids | - |
dc.title | Intense pulsed light in photoaging: a clinical, histopathological and immunohistochemical evaluation | - |
dc.title.alternative | Luz intensa pulsada no fotoenvelhecimento: avaliação clínica, histopatológica e imuno-histoquímica | - |
dc.type | article | - |
dc.rights.holder | Copyright SOC BRASILEIRA DERMATOLOGIA | - |
dc.identifier.pmid | 22281900 | - |
dc.subject.wos | Dermatology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 1129 | - |
hcfmusp.description.endpage | 1133 | - |
hcfmusp.description.issue | 6 | - |
hcfmusp.description.volume | 86 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000299512700010 | - |
hcfmusp.origem.id | 2-s2.0-84856615866 | - |
hcfmusp.publisher.city | RIO DE JANEIRO RJ | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 18 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDT Artigos e Materiais de Revistas Científicas - FM/MOT Artigos e Materiais de Revistas Científicas - HC/ICHC |
Files in This Item:
File | Description | Size | Format | |
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art_PATRIOTA_Intense_pulsed_light_in_photoaging_a_clinical_histopathological_2011_por.PDF | publishedVersion (Portuguese) | 218.14 kB | Adobe PDF | View/Open |
art_PATRIOTA_Intense_pulsed_light_in_photoaging_a_clinical_histopathological_2011_eng.PDF | publishedVersion (English) | 348.15 kB | Adobe PDF | View/Open |
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