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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | GRANGEIRO, Alexandre | - |
dc.contributor.author | ESCUDER, Maria Mercedes | - |
dc.contributor.author | MENEZES, Paulo Rossi | - |
dc.contributor.author | ALENCAR, Rosa | - |
dc.contributor.author | CASTILHO, Euclides Ayres de | - |
dc.date.accessioned | 2017-11-27T16:34:05Z | - |
dc.date.available | 2017-11-27T16:34:05Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | PLOS ONE, v.6, n.1, article ID e14585, 11p, 2011 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/23362 | - |
dc.description.abstract | Background: Worldwide, a high proportion of HIV-infected individuals enter into HIV care late. Here, our objective was to estimate the impact that late entry into HIV care has had on AIDS mortality rates in Brazil. Methodology/Principal Findings: We analyzed data from information systems regarding HIV-infected adults who sought treatment at public health care facilities in Brazil from 2003 to 2006. We initially estimated the prevalence of late entry into HIV care, as well as the probability of death in the first 12 months, the percentage of the risk of death attributable to late entry, and the number of avoidable deaths. We subsequently adjusted the annual AIDS mortality rate by excluding such deaths. Of the 115,369 patients evaluated, 50,358 (43.6%) had entered HIV care late, and 18,002 died in the first 12 months, representing a 16.5% probability of death in the first 12 months (95% CI: 16.3-16.7). By comparing patients who entered HIV care late with those who gained timely access, we found that the risk ratio for death was 49.5 (95% CI: 45.1-54.2). The percentage of the risk of death attributable to late entry was 95.5%, translating to 17,189 potentially avoidable deaths. Averting those deaths would have lowered the 2003-2006 AIDS mortality rate by 39.5%. Including asymptomatic patients with CD4(+) T cell counts >200 and <= 350 cells/mm(3) in the group who entered HIV care late increased this proportion by 1.8%. Conclusions/Significance: In Brazil, antiretroviral drugs reduced AIDS mortality by 43%. Timely entry would reduce that rate by a similar proportion, as well as resulting in a 45.2% increase in the effectiveness of the program for HIV care. The World Health Organization recommendation that asymptomatic patients with CD4(+) T cell counts <= 350 cells/mm(3) be treated would not have a significant impact on this scenario. | - |
dc.description.sponsorship | Brazilian National Ministry of Health | - |
dc.description.sponsorship | Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ, German Agency for Technical Cooperation) in Brazil | - |
dc.description.sponsorship | Brazilian Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, National Council for Scientific and Technological Development) | - |
dc.language.iso | eng | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.ispartof | Plos One | - |
dc.rights | openAccess | - |
dc.subject.other | antiretroviral therapy | - |
dc.subject.other | hiv-1-infected patients | - |
dc.subject.other | united-states | - |
dc.subject.other | gender-differences | - |
dc.subject.other | infected patients | - |
dc.subject.other | medical-care | - |
dc.subject.other | sao-paulo | - |
dc.subject.other | 1st year | - |
dc.subject.other | diagnosis | - |
dc.subject.other | settings | - |
dc.title | Late Entry into HIV Care: Estimated Impact on AIDS Mortality Rates in Brazil, 2003-2006 | - |
dc.type | article | - |
dc.rights.holder | Copyright PUBLIC LIBRARY SCIENCE | - |
dc.identifier.doi | 10.1371/journal.pone.0014585 | - |
dc.identifier.pmid | 21283618 | - |
dc.subject.wos | Multidisciplinary Sciences | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | ESCUDER, Maria Mercedes:Secretaria Estado Saude Sao Paulo, Inst Saude, Sao Paulo, Brazil | - |
hcfmusp.author.external | ALENCAR, Rosa:Secretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids, Sao Paulo, Brazil | - |
hcfmusp.description.articlenumber | e14585 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 6 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000286661400003 | - |
hcfmusp.origem.id | 2-s2.0-79551537508 | - |
hcfmusp.publisher.city | SAN FRANCISCO | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 50 | - |
hcfmusp.scopus.lastupdate | 2024-04-18 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/39 |
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