Lack of Association Between a 3 ' UTR VNTR Polymorphism of Dopamine Transporter Gene (SLC6A3) and ADHD in a Brazilian Sample of Adult Patients
Carregando...
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS INC
Autores
Citação
JOURNAL OF ATTENTION DISORDERS, v.15, n.4, p.305-309, 2011
Resumo
Objective: To investigate a possible association between a 3'UTR VNTR polymorphism of the dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of adult patients. Method: Study Case-control with 102 ADHD adult outpatients (DSM-IV criteria) and 479 healthy controls. The primers' sequence used were: 3'UTR-Forward: 5'TGT GGT GAT GGG AAC GGC CTG AG 3' and 3'UTR-Reverse: 5'CTT CCT GGA GGT CAC GGC TCA AGG 3'. Alleles of the 3'UTR were coded according to their number of repeats: 6- repeat 320 bp (allele 6), 8- repeat 400 bp (allele 8), 9-repeat 480 bp (allele 9), 10- repeat 480 bp (allele 10), and 11- repeat 520 bp (allele 11). Results: There were no allelic (chi(2) = 2.67, 5df, p = .75) and genotypic (chi(2) = 7.20, 1df, p = .61) association between adult ADHD and VNTR 3'UTR polymorphism of SLC6A3. Conclusion: Our findings do not support SLC6A3 as marker genetic susceptibility factor in adult ADHD. More comprehensive polymorphism coverage within the SLC6A3 region should be conducted in larger samples, including comparisons in clinical subgroups, and in samples with different ethnic backgrounds. (J. of Att. Dis. 2011; 15(4) 305-309)
Palavras-chave
association study, ADHD, case-control study, DAT1, dopamine, genetics
Referências
- American Psychological Association(APA), 1994, DIAGN STAT MAN MENT
- SPENCER T, 1995, ARCH GEN PSYCHIAT, V52, P434
- Krause KH, 2003, NEUROSCI BIOBEHAV R, V27, P605, DOI 10.1016/j.neubiorev.2003.08.012
- Schweitzer JB, 2003, NEUROPSYCHOPHARMACOL, V28, P967, DOI 10.1038/sj.npp.1300110
- Gizer IR, 2009, HUM GENET, V126, P51, DOI 10.1007/s00439-009-0694-x
- Faraone SV, 2000, BIOL PSYCHIAT, V48, P9, DOI 10.1016/S0006-3223(00)00889-1
- Franke B, 2008, AM J MED GENET B, V147B, P1576, DOI [10.1002/ajmg.b.30861, 10.1002/ajm.b.30861]
- Martinez D, 2001, NEUROPSYCHOPHARMACOL, V24, P553, DOI 10.1016/S0893-133X(00)00216-5
- Mill J, 2002, AM J MED GENET, V114, P975, DOI 10.1002/ajmg.10948
- Faraone SV, 2004, PSYCHIAT CLIN N AM, V27, P303, DOI 10.1016/S0193-953X(03)00090-X
- Miller GM, 2002, MOL PSYCHIATR, V7, P44, DOI 10.1038/sj/mp/4000921
- Cordeiro Q, 2009, REV BRAS PSIQUIATR, V31, P154, DOI 10.1590/S1516-44462009000200013
- Spencer T, 2005, BIOL PSYCHIAT, V57, P456, DOI 10.1016/j.biopsych.2004.11.043
- Solanto MV, 1998, BEHAV BRAIN RES, V94, P127, DOI 10.1016/S0166-4328(97)00175-7
- McGough JJ, 2004, AM J PSYCHIAT, V161, P1948, DOI 10.1176/appi.ajp.161.11.1948
- Waldman ID, 1998, AM J HUM GENET, V63, P1767, DOI 10.1086/302132
- Davidson MA, 2008, J ATTEN DISORD, V11, P628, DOI 10.1177/1087054707310878
- COOK EH, 1995, AM J HUM GENET, V56, P993
- Faraone SV, 2005, BIOL PSYCHIAT, V57, P1313, DOI 10.1016/j.biopsych.2004.11.024
- Polanczyk G, 2007, AM J PSYCHIAT, V164, P942, DOI 10.1176/appi.ajp.164.6.942
- Cordeiro Q, 2004, ARQ NEURO-PSIQUIAT, V62, P973, DOI 10.1590/S0004-282X2004000600008
- Fontana RD, 2007, ARQ NEURO-PSIQUIAT, V65, P134, DOI 10.1590/S0004-282X2007000100027
- Fuke S., 2001, Pharmacogenomics Journal, V1, P152
- Guardiola A, 2000, ARQ NEURO-PSIQUIAT, V58, P401, DOI 10.1590/S0004-282X2000000300001
- Guindalini C, 2005, PHARMACOGENET GENOM, V15, P891
- Poeta Lisiane Schilling, 2004, Revista Brasileira de Psiquiatria, V26, P150, DOI 10.1590/S1516-44462004000300004
- Pondé Milena Pereira, 2007, Arq Neuropsiquiatr, V65, P240, DOI 10.1590/S0004-282X2007000200010
- Silva MA, 2005, REV MED CHILE, V133, P1392, DOI 10.4067/S0034-98872005001100017
- SILVA MA, 2006, ARQUIVOS NEUROPSIQUI, V64, P563
- Silva Maria Aparecida da, 2009, Rev Bras Psiquiatr, V31, P390
- Terwilliger JD, 2002, CURR OPIN GENET DEV, V12, P726, DOI 10.1016/S0959-437X(02)0035X
- Vasconcelos MM, 2003, ARQ NEURO-PSIQUIAT, V61, P67, DOI 10.1590/S0004-282X2003000100012