Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions
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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
Citação
MICROBES AND INFECTION, v.13, n.12-13, p.1012-1017, 2011
Resumo
Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis.
Palavras-chave
Paracoccidioidomycosis, Langerin, Immune response
Referências
- Hunger RE, 2004, J CLIN INVEST, V113, P701, DOI 10.1172/JCI200419655
- Bursch LS, 2007, J EXP MED, V204, P3147, DOI 10.1084/jem.20071966
- Bousarghin L, 2005, J GEN VIROL, V86, P1297, DOI 10.1099/vir.0.80559-0
- Stambach NS, 2003, GLYCOBIOLOGY, V13, P401, DOI 10.1093/glycob/cwg045
- Quaresma JAS, 2009, AM J DERMATOPATH, V31, P527
- Nagao K, 2009, P NATL ACAD SCI USA, V106, P3312, DOI 10.1073/pnas.0807126106
- Banchereau J, 1998, NATURE, V392, P245, DOI 10.1038/32588
- Mc Dermott R, 2002, MOL BIOL CELL, V13, P317, DOI 10.1091/mbc.01-06-0300
- Poulin LF, 2007, J EXP MED, V204, P3119, DOI 10.1084/jem.20071724
- Merad M, 2009, BLOOD, V113, P3418, DOI 10.1182/blood-2008-12-180646
- de Witte L, 2007, NAT MED, V13, P367, DOI 10.1038/nm1541
- Brewig N, 2009, J IMMUNOL, V182, P774
- de Jong MAWP, 2010, MOL IMMUNOL, V47, P1216, DOI 10.1016/j.molimm.2009.12.016
- Valladeau J, 2000, IMMUNITY, V12, P71, DOI 10.1016/S1074-7613(00)80160-0
- Romani N, 2010, IMMUNOL REV, V234, P120, DOI 10.1111/j.0105-2896.2009.00886.x
- Asahina A, 2006, J DERMATOL SCI, V44, P1, DOI 10.1016/j.jdermsci.2006.07.002
- BIEBER T, 1988, BRIT J DERMATOL, V118, P385, DOI 10.1111/j.1365-2133.1988.tb02432.x
- BIRBECK MS, 1961, J INVEST DERMATOL, V37, P51, DOI 10.1038/jid.1961.80
- GIMENEZ MF, 1987, ARCH DERMATOL, V123, P479, DOI 10.1001/archderm.123.4.479
- Marques S. A., 2007, Anais Brasileiros de Dermatologia, V82, P411, DOI 10.1590/S0365-05962007000500003
- Pagliari C, 2003, AM J DERMATOPATH, V25, P107, DOI 10.1097/00000372-200304000-00003
- Pagliari C, 2002, MED MYCOL, V40, P407, DOI 10.1080/714031129
- Romani N, 2010, J INVEST DERMATOL, V130, P331
- Sandoval M, 1996, INT J SURG PATHOL, V3, P181
- STOITZNER R, 2003, J INVEST DERMATOL, V120, P266