Frequency and genotypic distribution of GB virus C (GBV-C) among Colombian population with Hepatitis B (HBV) or Hepatitis C (HCV) infection
Carregando...
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
BOTELHO, Livia
NISHIYA, Anna
GUTIERREZ, Maria F.
Citação
VIROLOGY JOURNAL, v.8, article ID 345, 7p, 2011
Resumo
Background: GB virus C (GBV-C) is an enveloped positive-sense ssRNA virus belonging to the Flaviviridae family. Studies on the genetic variability of the GBV-C reveals the existence of six genotypes: genotype 1 predominates in West Africa, genotype 2 in Europe and America, genotype 3 in Asia, genotype 4 in Southwest Asia, genotype 5 in South Africa and genotype 6 in Indonesia. The aim of this study was to determine the frequency and genotypic distribution of GBV-C in the Colombian population. Methods: Two groups were analyzed: i) 408 Colombian blood donors infected with HCV (n = 250) and HBV (n = 158) from Bogota and ii) 99 indigenous people with HBV infection from Leticia, Amazonas. A fragment of 344 bp from the 5' untranslated region (5' UTR) was amplified by nested RT PCR. Viral sequences were genotyped by phylogenetic analysis using reference sequences from each genotype obtained from GenBank (n = 160). Bayesian phylogenetic analyses were conducted using Markov chain Monte Carlo (MCMC) approach to obtain the MCC tree using BEAST v. 1.5.3. Results: Among blood donors, from 158 HBsAg positive samples, eight 5.06% (n = 8) were positive for GBV-C and from 250 anti-HCV positive samples, 3.2%(n = 8) were positive for GBV-C. Also, 7.7% (n = 7) GBV-C positive samples were found among indigenous people from Leticia. A phylogenetic analysis revealed the presence of the following GBV-C genotypes among blood donors: 2a (41.6%), 1 (33.3%), 3 (16.6%) and 2b (8.3%). All genotype 1 sequences were found in co-infection with HBV and 4/5 sequences genotype 2a were found in co-infection with HCV. All sequences from indigenous people from Leticia were classified as genotype 3. The presence of GBV-C infection was not correlated with the sex (p = 0.43), age (p = 0.38) or origin (p = 0.17). Conclusions: It was found a high frequency of GBV-C genotype 1 and 2 in blood donors. The presence of genotype 3 in indigenous population was previously reported from Santa Marta region in Colombia and in native people from Venezuela and Bolivia. This fact may be correlated to the ancient movements of Asian people to South America a long time ago.
Palavras-chave
Referências
- Mora MVA, 2011, INFECT GENET EVOL, V11, P103, DOI 10.1016/j.meegid.2010.10.003
- Barusruk Sahapat, 2006, Southeast Asian Journal of Tropical Medicine and Public Health, V37, P289
- Casteling A, 1998, J MED VIROL, V55, P103, DOI 10.1002/(SICI)1096-9071(199806)55:2<103::AID-JMV4>3.0.CO;2-6
- Tucker TJ, 1999, J MED VIROL, V59, P52, DOI 10.1002/(SICI)1096-9071(199909)59:1<52::AID-JMV9>3.0.CO;2-D
- Thompson JD, 1997, NUCLEIC ACIDS RES, V25, P4876, DOI 10.1093/nar/25.24.4876
- Linnen J, 1996, SCIENCE, V271, P505, DOI 10.1126/science.271.5248.505
- Posada D, 1998, BIOINFORMATICS, V14, P817, DOI 10.1093/bioinformatics/14.9.817
- Loureiro CL, 2002, J MED VIROL, V68, P357, DOI 10.1002/jmv.10211
- Moaven LD, 1996, MED J AUSTRALIA, V165, P369
- Seifried C, 2004, TRANSFUSION, V44, P268, DOI 10.1111/j.1537-2995.2004.00665.x
- Laskus T, 1997, J VIROL, V71, P7804
- Tillmann HL, 2001, ANTIVIR RES, V52, P83, DOI 10.1016/S0166-3542(01)00172-3
- Dawson GJ, 1996, J MED VIROL, V50, P97, DOI 10.1002/(SICI)1096-9071(199609)50:1<97::AID-JMV16>3.0.CO;2-V
- Stapleton JT, 2011, J GEN VIROL, V92, P233, DOI 10.1099/vir.0.027490-0
- SIMONS JN, 1995, NAT MED, V1, P564, DOI 10.1038/nm0695-564
- Konomi N, 1999, J CLIN MICROBIOL, V37, P3291
- Smith DB, 1997, J GEN VIROL, V78, P1533
- Bjorkman P, 2001, VOX SANG, V81, P148, DOI 10.1046/j.1423-0410.2001.00098.x
- Muerhoff AS, 2006, J MED VIROL, V78, P105, DOI 10.1002/jmv.20510
- Tanaka E, 1996, ANN INTERN MED, V125, P740
- Jarvis LM, 1996, LANCET, V348, P1352, DOI 10.1016/S0140-6736(96)04041-X
- Naito H, 1999, J CLIN MICROBIOL, V37, P1217
- Suzuki Y, 1999, J MOL EVOL, V48, P383, DOI 10.1007/PL00006482
- GonzalezPerez MA, 1997, J MED VIROL, V52, P149, DOI 10.1002/(SICI)1096-9071(199706)52:2<149::AID-JMV5>3.0.CO;2-3
- Muerhoff AS, 1996, J HEPATOL, V25, P379, DOI 10.1016/S0168-8278(96)80125-5
- Alter HJ, 1997, TRANSFUSION, V37, P569, DOI 10.1046/j.1537-2995.1997.37697335149.x
- Leary TP, 1996, J MED VIROL, V48, P60, DOI 10.1002/(SICI)1096-9071(199601)48:1<60::AID-JMV10>3.0.CO;2-A
- Berzsenyi MD, 2005, J CLIN VIROL, V33, P257, DOI 10.1016/j.jcv.2005.04.002
- Bouchardeau F, 2000, TRANSFUSION, V40, P875, DOI 10.1046/j.1537-2995.2000.40070875.x
- CAVALLISFORZA LL, 1991, SCI AM, V265, P72
- Cesaire R, 1999, J MED VIROL, V59, P160, DOI 10.1002/(SICI)1096-9071(199910)59:2<160::AID-JMV6>3.0.CO;2-Y
- DiBisceglie AM, 1996, ANN INTERN MED, V125, P772
- Ding X, 1999, VIRUS GENES, V19, P51, DOI 10.1023/A:1008188623062
- Drummond AJ, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-214
- El-Zayadi AR, 1999, J VIROL METHODS, V80, P53, DOI 10.1016/S0166-0934(99)00036-1
- Feucht HH, 1997, J CLIN MICROBIOL, V35, P767
- Feucht HH, 1996, LANCET, V347, P615
- Giret MTM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018407
- Hanci SY, 2008, MIKROBIYOL BUL, V42, P617
- Katayama K, 1998, ARCH VIROL, V143, P1063, DOI 10.1007/s007050050356
- KWOK S, 1989, NATURE, V339, P237, DOI 10.1038/339237a0
- Lampe E, 1998, CLIN DIAGN VIROL, V9, P1, DOI 10.1016/S0928-0197(97)10017-4
- Levi Jose Eduardo, 2003, Revista do Instituto de Medicina Tropical de Sao Paulo, V45, P75, DOI 10.1590/S0036-46652003000200004
- Ling BH, 1998, WORLD J GASTROENTERO, V4, P489
- Lyra AC, 2005, BRAZ J MED BIOL RES, V38, P767, DOI 10.1590/S0100-879X2005000500015
- Mora MVA, 2010, J MED VIROL, V82, P1889, DOI 10.1002/jmv.21908
- Muerhoff AS, 1997, J VIROL, V71, P6501
- Mukaide M, 1997, FEBS LETT, V407, P51, DOI 10.1016/S0014-5793(97)00136-1
- Naito H, 2001, J VIROL METHODS, V91, P3, DOI 10.1016/S0166-0934(00)00207-X
- Okamoto H, 1997, J GEN VIROL, V78, P737
- Oubina JR, 1999, VIRUS RES, V65, P121, DOI 10.1016/S0168-1702(99)00109-4
- Pinho JRR, 1999, J CLIN MICROBIOL, V37, P1634
- Ramezani A, 2008, INT J INFECT DIS, V12, P57, DOI 10.1016/j.ijid.2007.04.010
- Ramos R, 2004, MEM I OSWALDO CRUZ, V99, P639, DOI 10.1590/S0074-02762004000600019
- RIBEIRODOS S, 2002, EUR J CLIN MICROBIOL, V21, P438
- Tanaka Y, 1998, AM J TROP MED HYG, V59, P462
- Thomas DL, 1997, J INFECT DIS, V176, P586
- Wiwanitkit V., 2006, Journal of Pediatric Infectious Diseases, V1, P83
- ZANINOVIC V, 1994, AIDS RES HUM RETROV, V10, P97, DOI 10.1089/aid.1994.10.97
- Zhu WF, 2003, WORLD J GASTROENTERO, V9, P1739