Exercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female rats

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art_ROSSI_Exercise_training_attenuates_acute_hyperalgesia_in_streptozotocininduced_diabetic_2011.PDF (458.1 KB)
Citações na Scopus
26
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
ROSSI, Denise M.
NAVEGA, Marcelo T.
Citação
CLINICS, v.66, n.9, p.1615-1619, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats. METHODS: Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemic sedentary (HS)], normoglycemic trained rats (NT) and normoglycemic sedentary rats (NS). Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). One day after the last exercise protocol (60 min/day, five days/week for eight weeks) in the trained groups or after water stress exposure (ten min/twice a week) in the sedentary groups, the rats were subjected to a hot plate test. RESULTS: After eight weeks of swimming training, streptozotocin-induced diabetic rats presented a significantly lower body mass (trained: 219.5 +/- 29 g, sedentary: 217.8 +/- 23 g) compared with the normoglycemic groups (trained: 271 +/- 24 g, sedentary: 275.7 +/- 32 g). Interestingly, we did not find differences in blood glucose levels (mg/dl) between the trained and sedentary groups of the hyperglycemic or normoglycemic rats (HT: 360.2 +/- 66.6, HS: 391.7 +/- 66.7, NT: 83.8 +/- 14.0, NS: 77.5 +/- 10.1). In the hot plate test, the rats from the HT group presented a significantly lower latency than the other rats (HT: 11.7 +/- 7.38 s, HS: 7.02 +/- 7.38 s, NT: 21.21 +/- 7.64 s, NS: 22.82 +/- 7.82 s). CONCLUSION: Low-to-moderate swimming training for a long duration reduces thermal hyperalgesia during a hot plate test in streptozotocin-induced diabetic female rats.
Palavras-chave
Diabetes mellitus, Diabetic neuropathy, Pain sensitivity, Physical exercise, Swimming training, Hot plate test
URI
https://observatorio.fm.usp.br/handle/OPI/23582
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros