Accuracy of transient elastography-FibroScan (R), acoustic radiation force impulse (ARFI) imaging, the enhanced liver fibrosis (ELF) test, APRI, and the FIB-4 index compared with liver biopsy in patients with chronic hepatitis C

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Arquivos
art_RAGAZZO_Accuracy_of_transient_elastographyFibroScan_R_acoustic_radiation_force_2017.PDF (1.05 MB)
Citações na Scopus
42
Tipo de produção
article
Data de publicação
2017
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
LIMA, Fabiana Roberto
Citação
CLINICS, v.72, n.9, p.516-525, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: Although liver biopsy is the gold standard for determining the degree of liver fibrosis, issues regarding its invasiveness and the small amount of liver tissue evaluated can limit its applicability and interpretation in clinical practice. Non-invasive evaluation methods for liver fibrosis can address some of these limitations. The aim of this study was to evaluate the accuracy of transient elastography-FibroScan (R), acoustic radiation force impulse (ARFI), enhanced liver fibrosis (ELF), the aspartate aminotransferase-to-platelet ratio index (APRI), and the FIB-4 index compared with liver biopsy in hepatitis C. METHODS: We evaluated chronic hepatitis C patients who were followed at the Division of Clinical Gastroenterology and Hepatology, Hospital das Clinicas, Department of Gastroenterology of University of Sao Paulo School of Medicine, Sao Paulo, Brazil, and who underwent liver biopsy. The accuracy of each method was determined by a receiver operating characteristic (ROC) curve analysis, and fibrosis was classified as significant fibrosis (>= F2), advanced fibrosis (>= F3), or cirrhosis (F4). The Obuchowski method was also used to determine the diagnostic accuracy of each method at the various stages of fibrosis. In total, 107 FibroScan (R), 51 ARFI, 68 ELF, 106 APRI, and 106 FIB-4 analyses were performed. RESULTS: A total of 107 patients were included in the study. The areas under the ROC curve (AUROCs) according to fibrosis degree were as follows: significant fibrosis (>= F2): FibroScan (R) : 0.83, FIB-4: 0.76, ELF: 0.70, APRI: 0.69, and ARFI: 0.67; advanced fibrosis (>= F3): FibroScan (R) : 0.85, ELF: 0.82, FIB-4: 0.77, ARFI: 0.74, and APRI: 0.71; and cirrhosis (F4): APRI: 1, FIB-4: 1, FibroScan (R) : 0.99, ARFI: 0.96, and ELF: 0.94. The accuracies of transient elastography, ARFI, ELF, APRI and FIB-4 determined by the Obuchowski method were F0-F1: 0.81, 0.78, 0.44, 0.72 and 0.67, respectively; F1-F2: 0.73, 0.53, 0.62, 0.60, and 0.68, respectively; F2-F3: 0.70, 0.64, 0.77, 0.60, and 0.67, respectively; and F3-F4: 0.98, 0.96, 0.82, 1, and 1, respectively. CONCLUSION: Transient elastography remained the most effective method for evaluating all degrees of fibrosis. The accuracy of all methodologies was best at F4.
Palavras-chave
Hepatitis C Chronic, Liver Cirrhosis, Elastography, Biomarkers/Blood, Disease Progression, Data Accuracy
URI
https://observatorio.fm.usp.br/handle/OPI/24277
Referências
  1. Al Knawy B, 2007, LIVER INT, V27, P1166, DOI 10.1111/j.1478-3231.2007.01592.x
  2. Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
  3. Bamber J, 2013, ULTRASCHALL MED, V34, P169, DOI 10.1055/s-0033-1335205
  4. BEDOSSA P, 1994, HEPATOLOGY, V20, P15
  5. Bonder Alan, 2014, Curr Gastroenterol Rep, V16, P372, DOI 10.1007/s11894-014-0372-6
  6. Bota S, 2015, MED ULTRASON, V17, P200, DOI 10.11152/mu.2013.2066.172.arfi
  7. Bota S, 2013, LIVER INT, V33, P1138, DOI 10.1111/liv.12240
  8. Boursier J, 2013, HEPATOLOGY, V57, P1182, DOI 10.1002/hep.25993
  9. Bravo AA, 2001, NEW ENGL J MED, V344, P495, DOI 10.1056/NEJM200102153440706
  10. Bureau C, 2008, ALIMENT PHARM THER, V27, P1261, DOI 10.1111/j.1365-2036.2008.03701.x
  11. Carrilho FJ, 2010, CLINICS, V65, P1285, DOI 10.1590/S1807-59322010001200010
  12. Castera L, 2005, GASTROENTEROLOGY, V128, P343, DOI 10.1053/j.gastro.2004.11.018
  13. Castera L, 2008, J HEPATOL, V48, P835, DOI 10.1016/j.jhep.2008.02.008
  14. Castera L, 2007, GASTROEN CLIN BIOL, V31, P524, DOI 10.1016/S0399-8320(07)89422-X
  15. Castera L, 2010, HEPATOLOGY, V51, P828, DOI 10.1002/hep.23425
  16. Crisan D, 2012, HEPAT MON, V12, P177, DOI 10.5812/hepatmon.853
  17. da Silva RG, 2008, BRAZ J INFECT DIS, V12, P15, DOI 10.1590/S1413-86702008000100005
  18. de Ledinghen V, 2008, GASTROEN CLIN BIOL, V32, P58, DOI 10.1016/S0399-8320(08)73994-0
  19. Fagan KJ, 2015, LIVER INT, V35, P1673, DOI 10.1111/liv.12760
  20. Fierbinteanu-Braticevici C, 2009, WORLD J GASTROENTERO, V15, P5525, DOI 10.3748/wjg.15.5525
  21. Foucher J, 2006, GUT, V55, P403, DOI 10.1136/gut.2005.069153
  22. Friedrich-Rust M, 2012, J VIRAL HEPATITIS, V19, pE212, DOI 10.1111/j.1365-2893.2011.01537.x
  23. Gara N, 2013, CLIN GASTROENTEROL H, V11, P303, DOI 10.1016/j.cgh.2012.10.044
  24. Guechot J, 2012, CLIN CHEM LAB MED, V50, P693, DOI 10.1515/cclm-2011-0858
  25. Hong WK, 2013, CLIN MOL HEPATOL, V19, P370, DOI 10.3350/cmh.2013.19.4.370
  26. Herrero JI, 2014, GASTROENT HEPAT-BARC, V37, P233, DOI 10.1016/j.gastrohep.2013.10.009
  27. Juarez-Hernandez E, 2015, DIGEST DIS SCI, V60, P2177, DOI 10.1007/s10620-015-3611-2
  28. Li SM, 2014, WORLD J GASTROENTERO, V20, P9528, DOI 10.3748/wjg.v20.i28.9528
  29. Liao LY, 2015, ULTRASOUND MED BIOL, V41, P698, DOI 10.1016/j.ultrasmedbio.2014.09.030
  30. Lichtinghagen R, 2013, J HEPATOL, V59, P1365, DOI 10.1016/j.jhep.2013.03.016
  31. Martin J, 2015, DIGEST DIS SCI, V60, P1841, DOI 10.1007/s10620-015-3531-1
  32. Mederacke I, 2009, LIVER INT, V29, P1500, DOI 10.1111/j.1478-3231.2009.02100.x
  33. Myers RP, 2012, J HEPATOL, V56, P564, DOI 10.1016/j.jhep.2011.10.007
  34. Myers RP, 2010, LIVER INT, V30, P1471, DOI 10.1111/j.1478-3231.2010.02331.x
  35. Nadebaum D, 2014, LIV M NOV 7 11 BOST
  36. Nierhoff J, 2013, EUR RADIOL, V23, P3040, DOI 10.1007/s00330-013-2927-6
  37. Nishikawa T, 2014, WORLD J GASTROENTERO, V20, P1289, DOI 10.3748/wjg.v20.i5.1289
  38. Obuchowski NA, 2006, STAT MED, V25, P481, DOI 10.1002/sim.2228
  39. Obuchowski NA, 2001, STAT MED, V20, P3261, DOI 10.1002/sim.944
  40. Paranagua-Vezozzo DC, 2014, ANN HEPATOL, V13, P386
  41. Parkes J, 2011, J VIRAL HEPATITIS, V18, P23, DOI 10.1111/j.1365-2893.2009.01263.x
  42. Parkes J, 2010, GUT, V59, P1245, DOI 10.1136/gut.2009.203166
  43. Perazzo H, 2015, LIVER INT, V35, P1533, DOI 10.1111/liv.12551
  44. Petersen JR, 2014, J CLIN GASTROENTEROL, V48, P370, DOI 10.1097/MCG.0b013e3182a87e78
  45. Pinzani M, 2010, GUT, V59, P1165, DOI 10.1136/gut.2010.214932
  46. Piscaglia F, 2014, EUR J RADIOL, V83, P450, DOI 10.1016/j.ejrad.2013.06.009
  47. Poynard Thierry, 2011, Gastroenterol Hepatol (N Y), V7, P445
  48. Regev A, 2002, AM J GASTROENTEROL, V97, P2614
  49. Rosenberg WMC, 2004, GASTROENTEROLOGY, V127, P1704, DOI 10.1053/j.gastro.2004.08.052
  50. Rustagi Tarun, 2010, Trop Gastroenterol, V31, P199
  51. Sebastiani G, 2006, WORLD J GASTROENTERO, V12, P3682
  52. Serejo F., 2007, J Port Gastrenterol., V14, P8
  53. Simundic Ana-Maria, 2009, EJIFCC, V19, P203
  54. Sporea I, 2011, HEPAT MON, V11, P532
  55. Vallet-Pichard A, 2007, HEPATOLOGY, V46, P32, DOI 10.1002/hep.21669
  56. Wahl K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051906
  57. Wai CT, 2003, HEPATOLOGY, V38, P518, DOI 10.1053/jhep.2003.50346
  58. World Health Organization, HEP C
  59. You SC, 2015, WORLD J GASTROENTERO, V21, P1158, DOI 10.3748/wjg.v21.i4.1158
  60. Ziol M, 2005, HEPATOLOGY, V41, P48, DOI 10.1002/hep.20506

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - ODS/03