Micronucleus frequency in children exposed to biomass burning in the Brazilian Legal Amazon region: a control case study
Carregando...
Citações na Scopus
50
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
SISENANDO, Herbert Ary
MEDEIROS, Silvia Regina Batistuzzo de
ARTAXO, Paulo
HACON, Sandra de Souza
Citação
BMC ORAL HEALTH, v.12, article ID 6, 7p, 2012
Resumo
Background: The Amazon represents an area of 61% of Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance of agribusiness. Composition of the atmosphere is controlled by several natural and anthropogenic processes, and emission from biomass burning is one with the major impact on human health. The aim of this study was to evaluate genotoxic potential of air pollutants generated by biomass burning through micronucleus assay in exfoliated buccal cells of schoolchildren in the Brazilian Amazon region. Methods: The study was conducted during the dry seasons in two regions of the Brazilian Amazon. The assay was carried out on buccal epithelial cells of 574 schoolchildren between 6-16 years old. Results: The results show a significant difference between micronucleus frequencies in children exposed to biomass burning compared to those in a control area. Conclusions: The present study demonstrated that in situ biomonitoring using a sensitive and low cost assay (buccal micronucleus assay) may be an important tool for monitoring air quality in remote regions. It is difficult to attribute the increase in micronuclei frequency observed in our study to any specific toxic element integrated in the particulate matters. However, the contribution of the present study lies in the evidence that increased exposure to fine particulate matter generates an increased micronuclei frequency in oral epithelial cells of schoolchildren.
Palavras-chave
Referências
- Abbas I, 2011, J APPL TOXICOL
- Alves ND, 2011, ECOTOX ENVIRON SAFE, V74, P1427, DOI 10.1016/j.ecoenv.2011.04.007
- Ansari AS, 2003, 12 WORLD FOR C QUEB
- Artaxo P, 2002, J GEOPHYS RES, V107
- Bateson TF, 2008, J TOXICOL ENV HEAL A, V71, P238, DOI 10.1080/15287390701598234
- Bonassi S, 2011, MUTAT RES-REV MUTAT, V728, P88, DOI 10.1016/j.mrrev.2011.06.005
- Bornholdt J, 2002, MUTAT RES-GEN TOX EN, V520, P63, DOI 10.1016/S1383-5718(02)00176-6
- Castro Hermano Albuquerque de, 2009, Cien Saude Colet, V14, P2083
- Cederberg C, 2011, ENVIRON SCI TECHNOL, V45, P1773, DOI 10.1021/es103240z
- Chen C, 2006, MUTAGENESIS, V21, P131, DOI 10.1093/mutage/gel007
- Erdinger L, 2005, ENVIRON SCI POLLUT R, V12, P10, DOI 10.1065/espr2004.04.196
- Fenech M, 2009, MUTAGENESIS, V24, P199, DOI 10.1093/mutage/gen065
- Ferreira DAC, 2008, CIENC HOJE, V42, P26
- Freitas SR, 2009, ATMOS CHEM PHYS, V9, P2843
- Grigg J, 2008, RES REP HLTH EFF I, V134, P1
- Grigg J, 2008, RES REP HLTH EFF I, V134, P25
- HACON S, 1995, WATER AIR SOIL POLL, V80, P273, DOI 10.1007/BF01189677
- Heuser VD, 2007, TOXICOLOGY, V232, P235, DOI 10.1016/j.tox.2007.01.011
- Holland N, 2008, MUTAT RES-REV MUTAT, V659, P93, DOI 10.1016/j.mrrev.2008.03.007
- Huen K, 2006, ENVIRON MOL MUTAGEN, V47, P236, DOI 10.1002/em.20193
- Iarmarcovai G, 2008, MUTAT RES-REV MUTAT, V658, P215, DOI 10.1016/j.mrrev.2007.10.001
- Isidori M, 2003, CHEMOSPHERE, V52, P121, DOI 10.1016/S0045-6535(03)00183-8
- Iurchenko VV, 2007, GIG SANIT, V6, P83
- Lahiri T, 2000, INDIAN J MED RES, V112, P21
- Lindberg HK, 2007, MUTAT RES-FUND MOL M, V617, P33, DOI 10.1016/j.mrfmmm.2006.12.002
- Magalhaes D, 2007, QUIM NOVA, V30, P577, DOI 10.1590/S0100-40422007000300014
- Maimulov V G, 1998, Tsitologiia, V40, P686
- Moraes MAFD, 2007, EC APLICADA, V11, P605
- Nastos PT, 2010, ENVIRON HEALTH-GLOB, V9, DOI 10.1186/1476-069X-9-45
- Neri M, 2003, MUTAT RES-REV MUTAT, V544, P243, DOI 10.1016/j.mrrev.2003.06.009
- PAHO, 2005, ASS HLTH EFF AMB AIR
- Pedersen M, 2006, MUTAT RES-GEN TOX EN, V608, P112, DOI 10.1016/j.mrgentox.2006.02.013
- Rosa Antonia Maria, 2008, J Bras Pneumol, V34, P575, DOI 10.1590/S1806-37132008000800006
- Silva Dias M.A.E, 2005, ACTA AMAZON, V35, P215, DOI 10.1590/S0044-59672005000200011
- Sisenando HA, 2011, ENVIRON HEALTH-GLOB, V10, DOI 10.1186/1476-069X-10-41
- Sychova L. P., 2008, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, P19
- TOLBERT PE, 1992, MUTAT RES, V271, P69, DOI 10.1016/0165-1161(92)90033-I
- van Leeuwen DM, 2008, CARCINOGENESIS, V29, P977, DOI 10.1093/carcin/bgn065
- Woodruff TJ, 2004, PEDIATRICS, V113, P1133