Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, Sao Paulo, Brazil

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art_GUIMARAES_Genetic_ancestry_effects_on_the_distribution_of_tolllike_2018.PDF (559.97 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
BAJAY, Miklos Maximiliano
WUNDERLICH, Gerhard
SANTOS, Sidney E.
Citação
HUMAN IMMUNOLOGY, v.79, n.2, p.101-108, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The innate immune system governed by toll -like receptors (TLRs) provides the first line of defense against pathogens. Surface -localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes were shown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune -related genes. To verify the influence of Brazilian population admixture on the distribution of polymorphisms in TLRs, we analyzed the genotype frequencies of 24 polymorphisms distributed across five TLR genes in a Southeastern Brazilian population where autochthonous cases of malaria occur in small foci of transmission. The estimation of ancestry showed mainly European ancestry (63%) followed by African ancestry (22%). Mean proportions of European ancestry differed significantly between the genotypes of the TLR1 (1602S) gene and in the TLR6 (P249S) gene. The chance of having the G allele in TLR1 gene increases as European ancestry increases as well as the chance of having the T allele in the TLR6 gene. The 602S allele is related to a ""hypo -responsiveness"" possibly explaining the high prevalence of asymptomatic malaria cases in areas of Southeastern Brazil. Our results underline the necessity to include informative ancestry markers in genetic association studies in order to avoid biased results.
Palavras-chave
TLRs, Genetic polymorphism, Gene frequency, Brazilian population
URI
https://observatorio.fm.usp.br/handle/OPI/25853
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - ODS/03