Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/2778
Title: Influence of genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin receptor B2 on treadmill exercise test responses
Authors: NUNES, R. A. BeloBARROSO, L. P.SCHMIDT, R. T.BARRETO, D. D.FREITAS, H. F.PEREIRA, A. C.KRIEGER, J. E.MANSUR, A. J.
Citation: EUROPEAN HEART JOURNAL, v.33, suppl.1, p.872-872, 2012
Abstract: Purpose: Treadmill exercise testing responses have been associated with cardiovascular prognosis in individuals without overt heart disease. Neurohumoral and nitric oxide responses may influence cardiovascular performance during exercise. The aim of this study was evaluate associations between genetic polymorphisms of alpha-adrenergic receptors (ADRA1A, ADRA2A and ADRA2B), endothelial nitric oxide synthase (eNOS) and bradykin receptor B2 (BK2R) and treadmill exercise test responses in individuals without overt heart disease. Method: We enrolled 766 (417 women and 349 men) asymptomatic subjects. We selected the following variables during a maximal symptom-limited treadmill exercise test: exercise capacity, chronotropic reserve, maximum heart-rate achieved, heart-rate recovery, exercise systolic blood pressure, exercise diastolic blood pressure and systolic blood pressure recovery. Genotypes for the ADRA1A Arg347Cys (rs1048101), ADRA2A C1780T (rs553668), ADRA2B Del 301-303 (rs28365031), eNOS T786C (rs2070744), eNOS Glu298Asp (rs1799983) and BK2R (rs5810761) polymorphisms were assessed by polymerase chain reaction (PCR) followed by high resolution melting analysis. Laboratory and demographic data were collected for all participants. Statistical analysis was performed with multiple regression models for women and men. Results: The genotype frequencies were under Hardy-Weinberg equilibrium, except for the ADRA2B Del301-303 polymorphism. In the multivariated analysis the ADRA2A C1780T polymorphism was significantly associated with exercise diastolic blood pressure in both sexes. Exercise diastolic blood pressure was higher in individuals with TT genotype than in C allel carriers (P=0.003 for women; P=0.007 for men) (Table 1). The other polymorphisms did not influence significantly the treadmill exercise test responses. Conclusion: The ADRA2A C1780T influenced the exercise diastolic blood pressure in both sexes. This finding suggests that this polymorphism may be a marker of blood pressure response during exercise.
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Comunicações em Eventos - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/13
LIM/13 - Laboratório de Genética e Cardiologia Molecular


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