Multi-ethnic genome-wide association study for atrial fibrillation

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art_ROSELLI_Multiethnic_genomewide_association_study_for_atrial_fibrillation_2018.PDF (2.53 MB)
Citações na Scopus
443
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
ROSELLI, Carolina
CHAFFIN, Mark D.
WENG, Lu-Chen
AESCHBACHER, Stefanie
AHLBERG, Gustav
ALBERT, Christine M.
ALMGREN, Peter
ALONSO, Alvaro
ANDERSON, Christopher D.
ARAGAM, Krishna G.
Citação
NATURE GENETICS, v.50, n.9, p.1225-+, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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URI
https://observatorio.fm.usp.br/handle/OPI/29395
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/02