Survival and prognosis of young adults with gastric cancer

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art_CORMEDI_Survival_and_prognosis_of_young_adults_with_gastric_2018.PDF (1.34 MB)
Citações na Scopus
22
Tipo de produção
article
Data de publicação
2018
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
CORMEDI, Marina Candido Visontai
KATAYAMA, Maria Lucia Hirata
GUINDALINI, Rodrigo Santa Cruz
FARAJ, Sheila Friedrich
FOLGUEIRA, Maria Aparecida Azevedo Koike
Citação
CLINICS, v.73, suppl.1, article ID UNSP e651s, 7p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sao Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA ( <= 40 years; N.71), older adult (OA: 41 to 65 years; N=129) and elderly (E: >= 66 years; N=94). Differences were assessed through Pearson's chi(2) test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; p <0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.
Palavras-chave
Stomach Neoplasms, Survival, Young Adult
URI
https://observatorio.fm.usp.br/handle/OPI/29422
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03