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https://observatorio.fm.usp.br/handle/OPI/29790
Title: | Low serum levels of CCL2 are associated with worse prognosis in patients with Acute Coronary Syndrome: 2-year survival analysis |
Authors: | LEOCADIO, Paola Caroline Lacerda; MENTA, Penelope Lacrisio dos Reis; DIAS, Melissa Tainan Silva; FRAGA, Julia Rodrigues; GOULART, Alessandra Carvalho; SANTOS, Itamar Souza; LOTUFO, Paulo Andrade; BENSENOR, Isabela Martins; ALVAREZ-LEITE, Jacqueline Isaura |
Citation: | BIOMEDICINE & PHARMACOTHERAPY, v.109, p.1411-1416, 2019 |
Abstract: | Inflammation is very important in Acute Coronary Syndrome (ACS) as well as in cardiac remodeling after an acute myocardial infarction (MI). Our study examined the prognostic value of Chemokine (C-C motif) ligand 2 (CCL2) in patients with ACS in the ERICO (Strategy of Registry of Acute Coronary Syndrome) study. We evaluated serum samples from 803 patients. The prognostic value of CCL2 was evaluated at the 2-year follow-up, according to cutoff points established by the median. Kaplan-Meier curves and Cox regression were used for analysis of all-cause mortality, cardiovascular mortality, and a combined outcome of fatal myocardial infarction or new non-fatal MI. There were 115 deaths from all causes, 78 deaths due to cardiovascular causes and 67 events in combined outcomes. CCL2 levels below the median (<= 100.9 pg/mL) were associated with increased risk of MI death or new non-fatal MI, even after model adjustment. Low serum levels of CCL2 shows a significant association with fatal or new non-fatal MI. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/20 Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - ODS/03 |
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