Absence of Plasmodium falciparum K13 Propeller Domain Polymorphisms among Field Isolates Collected from the Brazilian Amazon Basin between 1984 and 2011
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Citações na Scopus
5
Tipo de produção
article
Data de publicação
2018
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER SOC TROP MED & HYGIENE
Autores
INOUE, Juliana
JOVEL, Irina
MORRIS, Ulrika
AYDIN-SCHMIDT, Berit
ISLAM, Atiqul
BJORKMAN, Anders
MARTENSSON, Andreas
Citação
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.99, n.6, p.1504-1507, 2018
Resumo
Artemisinin resistance, presently confined to Southeast Asia and associated with mutations in the Plasmodium falciparum K13 (PfK13) propeller domain, represents a serious threat to global malaria control. This study aimed to provide baseline information for future artemisinin resistance surveillance, by analyzing the PfK13 propeller domain in P. falciparum field isolates collected from the Brazilian Amazon Basin between 1984 and 2011. A total of 152 P. falciparum mono-infections were assessed, of which 118 (78%) were collected before and 34 (22%) after the introduction of artemisinin-based combination therapy (ACT) in 2006. An 849-base pair fragment encoding the PfK13 propeller was amplified by nested polymerase chain reaction and sequenced in both directions. The sequences were compared with the reference sequence of P. falciparum 3D7. All samples showed wild-type sequences, thus, no mutations were observed. The results are in agreement with other recent reports and do not provide evidence for presence of PfK13 propeller domain polymorphisms associated with artemisinin resistance among P. falciparum field isolates in the Brazilian Amazon Basin neither before nor after the implementation of ACT.
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Referências
- Ariey F, 2014, NATURE, V505, P50, DOI 10.1038/nature12876
- Chenet SM, 2016, J INFECT DIS, V213, P1472, DOI 10.1093/infdis/jiv752
- Dondorp AM, 2009, NEW ENGL J MED, V361, P455, DOI 10.1056/NEJMoa0808859
- Duarte EC, 1996, AM J TROP MED HYG, V54, P197, DOI 10.4269/ajtmh.1996.54.197
- Ferreira MU, 2016, MALARIA J, V15, DOI 10.1186/s12936-016-1335-1
- Huang F, 2015, J INFECT DIS, V212, P1629, DOI 10.1093/infdis/jiv249
- Kyaw MP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057689
- Ladeia-Andrade S, 2016, AM J TROP MED HYG, V95, P148, DOI 10.4269/ajtmh.16-0017
- Menard D, 2016, NEW ENGL J MED, V374, P2453, DOI 10.1056/NEJMoa1513137
- Ministry of Health of Brazil, 2018, B MAL
- Ministry of Health of Brazil, 2010, GUIA PRAT TRAT MAL B
- Mita T, 2016, ANTIMICROB AGENTS CH, V60, P3340, DOI 10.1128/AAC.02370-15
- Mita T, 2011, J INFECT DIS, V204, P1980, DOI 10.1093/infdis/jir664
- Mita T, 2010, ACTA TROP, V114, P166, DOI 10.1016/j.actatropica.2009.07.008
- Musset L, 2014, MEM I OSWALDO CRUZ, V109, P525, DOI 10.1590/0074-0276140031
- Phyo AP, 2012, LANCET, V379, P1960, DOI 10.1016/S0140-6736(12)60484-X
- Pribluda VS, 2014, MALARIA J, V13, DOI 10.1186/1475-2875-13-77
- Santelli AC, 2012, MALARIA J, V11, DOI 10.1186/1475-2875-11-286
- Straimer J, 2015, SCIENCE, V347, P428, DOI 10.1126/science.1260867
- Hien TT, 2012, MALARIA J, V11, DOI 10.1186/1475-2875-11-355
- Vreden SGS, 2013, MEM I OSWALDO CRUZ, V108, P968, DOI 10.1590/0074-0276130167
- Wellems TE, 2009, J CLIN INVEST, V119, P2496, DOI 10.1172/JCI38307
- WHO, 2017, ART ART BAS COMB THE
- WOODEN J, 1993, PARASITOL TODAY, V9, P303, DOI 10.1016/0169-4758(93)90131-X
- World Health Organization, 2015, STAT REP ART ACT RES