Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/29949
Title: | Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus |
Authors: | COSTA, Antonio Charlys da; LUCHS, Adriana; MILAGRES, Flavio Augusto de Padua; KOMNINAKIS, Shirley Vasconcelos; GILL, Danielle Elise; LOBATO, Marcia Cristina Alves Brito Sayao; BRUSTULIN, Rafael; CHAGAS, Rogerio Togisaki das; ABRAO, Maria de Fatima Neves dos Santos; SOARES, Cassia Vitoria de Deus Alves; DENG, Xutao; SABINO, Ester Cerdeira; DELWART, Eric; LEAL, Elcio |
Citation: | VIRUSES-BASEL, v.10, n.10, article ID 520, 12p, 2018 |
Abstract: | Here we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus genomes showed that the breakpoint found in the Brazilian strain (SAFV-BR-193) is indeed a recombination hotspot. Notably, this hotspot is located just one nucleotide after the ribosomal frameshift GGUUUUU motif in the SAFV genome. Empirical studies will be necessary to determine if this motif also affects the binding affinity of RNA-dependent RNA-polymerase (RdRp) and therefore increases the changes of RdRp swap between molecules during the synthesis of viral genomes. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/46 Artigos e Materiais de Revistas Científicas - LIM/49 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_COSTA_Recombination_Located_over_2A2B_Junction_Ribosome_Frameshifting_Region_2018.PDF | publishedVersion (English) | 2.04 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.