Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus

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art_COSTA_Recombination_Located_over_2A2B_Junction_Ribosome_Frameshifting_Region_2018.PDF (1.99 MB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
LUCHS, Adriana
KOMNINAKIS, Shirley Vasconcelos
LOBATO, Marcia Cristina Alves Brito Sayao
BRUSTULIN, Rafael
CHAGAS, Rogerio Togisaki das
ABRAO, Maria de Fatima Neves dos Santos
SOARES, Cassia Vitoria de Deus Alves
Citação
VIRUSES-BASEL, v.10, n.10, article ID 520, 12p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Here we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus genomes showed that the breakpoint found in the Brazilian strain (SAFV-BR-193) is indeed a recombination hotspot. Notably, this hotspot is located just one nucleotide after the ribosomal frameshift GGUUUUU motif in the SAFV genome. Empirical studies will be necessary to determine if this motif also affects the binding affinity of RNA-dependent RNA-polymerase (RdRp) and therefore increases the changes of RdRp swap between molecules during the synthesis of viral genomes.
Palavras-chave
saffold virus, cardiovirus, virome, picornavirus, ribosomal frameshifting, GGUUUUU motif, RNA-dependent RNA-polymerase
URI
https://observatorio.fm.usp.br/handle/OPI/29949
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - LIM/49