Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

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art_TOVO-RODRIGUES_Is_intrauterine_exposure_to_acetaminophen_associated_with_emotional_2018.PDF (615.25 KB)
Citações na Scopus
30
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
TOVO-RODRIGUES, Luciana
SCHNEIDER, Bruna Celestino
MARTINS-SILVA, Thais
DEL-PONTE, Bianca
MOLA, Christian Loret de
SCHULER-FACCINI, Lavinia
VIANNA, Fernanda Sales Luiz
MUNHOZ, Tiago N.
ENTIAUSPE, Ludmila
SILVEIRA, Mariangela Freitas
Citação
BMC PSYCHIATRY, v.18, article ID 368, 11p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BackgroundLongitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11years in a low-middle income country.MethodsWe performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression.ResultsAcetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1-28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR]=1.47; 95% CI: 1.07-2.02) and hyperactivity/inattention (OR=1.42; 95% CI: 1.06-1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR=1.31 (95% CI: 0.99-1.73) for emotional problems and OR=1.25 (95% CI: 0.95-1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls.ConclusionThe effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6years of age, for girls, no association was observed.
Palavras-chave
Acetaminophen (paracetamol), Prenatal exposure, Birth cohort, Behavioral symptoms
URI
https://observatorio.fm.usp.br/handle/OPI/30034
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/39