Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

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art_HOADLEY_CellofOrigin_Patterns_Dominate_the_Molecular_Classification_of_10000_2018.PDF (7.49 MB)
Citações na Scopus
1358
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CELL PRESS
Autores
HOADLEY, Katherine A.
YAU, Christina
HINOUE, Toshinori
WOLF, Denise M.
LAZAR, Alexander J.
DRILL, Esther
SHEN, Ronglai
TAYLOR, Alison M.
CHERNIACK, Andrew D.
THORSSON, Vesteinn
Citação
CELL, v.173, n.2, p.291-304.e6, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.
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URI
https://observatorio.fm.usp.br/handle/OPI/30101
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - ODS/03