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https://observatorio.fm.usp.br/handle/OPI/31020
Title: | Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases |
Authors: | FUTSCH, Nicolas; PRATES, Gabriela; MAHIEUX, Renaud; CASSEB, Jorge; DUTARTRE, Helene |
Citation: | VIRUSES-BASEL, v.10, n.12, article ID 691, 17p, 2018 |
Abstract: | Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and of a malignant lymphoproliferation, called the adult T-cell leukemia/lymphoma (ATLL). The mechanisms through which the HTLV-1 induces these diseases are still unclear, but they might rely on immune alterations. HAM/TSP is associated with an impaired production of pro-inflammatory cytokines and chemokines, such as IFN-, TNF-, CXCL9, or CXCL10. ATLL is associated with high levels of IL-10 and TGF-. These immunosuppressive cytokines could promote a protumoral micro-environment. Moreover, HTLV-1 infection impairs the IFN-I production and signaling, and favors the IL-2, IL-4, and IL-6 expression. This contributes both to immune escape and to infected cells proliferation. Here, we review the landscape of cytokine dysregulations induced by HTLV-1 infection and the role of these cytokines in the HTLV-1-associated diseases progression. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/56 Artigos e Materiais de Revistas Científicas - ODS/03 |
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