Brain Structure in Obsessive-Compulsive Disorder: The OCD Brain Imaging Consortium (OBIC) Multi-Center Voxel-Based Morphometry Study
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Citações na Scopus
Tipo de produção
conferenceObject
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
HEUVEL, Odile A. van den
ALONSO, Pino
SCHWEREN, Lizanne J. S.
MATAIX-COLS, David
VELTMAN, Dick J.
MENCHON, Jose M.
LOCHNER, Christine
NAKAMAE, Takashi
KWON, Jun Soo
Citação
BIOLOGICAL PSYCHIATRY, v.71, n.8, suppl.S, p.179S-180S, 2012
Resumo
Background: Voxel-based morphometry (VBM) studies in obsessive-compulsive disorder (OCD) have shown altered regional grey (GM) and white matter (WM) volume of frontal-striatal and limbic regions. Recent meta-analyses were usefulto evaluate the consistency across individual VBM studies. However, a mega-analysis of pooled data provides increased statistical power to study more subtle abnormalities or specific demographic and clinical parameters. Methods: By combining resources, the OCD Brain Imaging Consortium (OBIC) enabled a multi-center mega-analysis on 1.5 Tesla T1-weighted MRI scans of 446 OCD patients and 388 controls, using DARTEL VBM (SPM8). Analyses included two-sample T tests for group comparisons (e.g., patients vs. controls, medicated vs. non-medicated patients) and regression analyses to study the effects of age, symptom profiles, and disease severity on regional GM and WM volume. Effects are reported at p<0.05 FWE-corrected. Results: OCD patients have significantly decreased GM volume of the dorsomedial prefrontal, insular and orbitofrontal cortex. Regional WM volume was decreased in the frontal regions and thalamus, areas connecting prefrontal cortex and basal ganglia. A group x age effect was found at lower statistical significance (p<0.001 uncorrected) in the bilateral striatum and insular cortex, suggesting relative preservation of volume in the striatum and relative loss of volume in the insula with increasing age in OCD patients compared with controls. There was no effect of disease severity and medication on regional GM or WM volume. Conclusions: OCD patients show altered GM and WM volume of frontalstriatal and limbic regions, possibly partly related to altered brain development and maturation during life.
Palavras-chave
obsessive-compulsive, Voxel-based morphometry, multi-center, frontal-striatal, limbic