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https://observatorio.fm.usp.br/handle/OPI/31787
Title: | Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis |
Authors: | PINHO, Flaviane Alves de; VENDRAME, Celia Maria Vieira; MACIEL, Bruna Leal Lima; SILVA, Lucilene dos Santos; MIYASHIRO, Samantha Ive; JERONIMO, Selma Maria Bezerra; GOTO, Hiro |
Citation: | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.100, n.4, p.808-815, 2019 |
Abstract: | We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine production. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 |
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