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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | PINHO, Flaviane Alves de | - |
dc.contributor.author | VENDRAME, Celia Maria Vieira | - |
dc.contributor.author | MACIEL, Bruna Leal Lima | - |
dc.contributor.author | SILVA, Lucilene dos Santos | - |
dc.contributor.author | MIYASHIRO, Samantha Ive | - |
dc.contributor.author | JERONIMO, Selma Maria Bezerra | - |
dc.contributor.author | GOTO, Hiro | - |
dc.date.accessioned | 2019-05-30T13:38:05Z | - |
dc.date.available | 2019-05-30T13:38:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.100, n.4, p.808-815, 2019 | - |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/31787 | - |
dc.description.abstract | We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine production. | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2010/16257-2] | - |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado da Bahia [1780-2007] | - |
dc.description.sponsorship | Conselho Nacional de Pesquisa [484499/2006] | - |
dc.description.sponsorship | Seropidemiology and Immunobiology Laboratory [LIM/38] | - |
dc.description.sponsorship | National Institutes of Health [AI 030639] | - |
dc.language.iso | eng | - |
dc.publisher | AMER SOC TROP MED & HYGIENE | eng |
dc.relation.ispartof | American Journal of Tropical Medicine and Hygiene | - |
dc.rights | restrictedAccess | eng |
dc.subject.other | tumor-necrosis-factor | eng |
dc.subject.other | interferon-gamma | eng |
dc.subject.other | igf-i | eng |
dc.subject.other | hematopoietic activity | eng |
dc.subject.other | bone-marrow | eng |
dc.subject.other | mouse model | eng |
dc.subject.other | erythropoiesis | eng |
dc.subject.other | expression | eng |
dc.subject.other | cytokines | eng |
dc.title | Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis | eng |
dc.type | article | eng |
dc.rights.holder | Copyright AMER SOC TROP MED & HYGIENE | eng |
dc.identifier.doi | 10.4269/ajtmh.17-0982 | - |
dc.identifier.pmid | 30761980 | - |
dc.subject.wos | Public, Environmental & Occupational Health | eng |
dc.subject.wos | Tropical Medicine | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | PINHO, Flaviane Alves de:Univ Sao Paulo, Inst Med Trop Sao Paulo, Sao Paulo, Brazil; Univ Fed Bahia, Dept Anat Patol & Clin, Escola Med Vet & Zootecnia, Salvador, BA, Brazil | - |
hcfmusp.author.external | MACIEL, Bruna Leal Lima:Univ Fed Rio Grande do Norte, Dept Nutricao, Ctr Ciencias Saude, Natal, RN, Brazil | - |
hcfmusp.author.external | SILVA, Lucilene dos Santos:Univ Fed Piaui, Setor Patol Anim, Ctr Ciencias Agr, Teresina, Brazil | - |
hcfmusp.author.external | MIYASHIRO, Samantha Ive:Univ Sao Paulo, Dept Clin Med, Fac Med Vet & Zootecnia, Sao Paulo, Brazil | - |
hcfmusp.author.external | JERONIMO, Selma Maria Bezerra:Univ Fed Rio Grande do Norte, Dept Bioquim, Ctr Biociencias, Natal, RN, Brazil; Univ Fed Rio Grande do Norte, Inst Trop Med Rio Grande Norte, Natal, RN, Brazil; Natl Inst Sci & Technol Trop Dis, Natal, RN, Brazil | - |
hcfmusp.description.beginpage | 808 | - |
hcfmusp.description.endpage | 815 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 100 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000467037100011 | - |
hcfmusp.origem.id | 2-s2.0-85064239262 | - |
hcfmusp.publisher.city | MCLEAN | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1476-1645 | - |
hcfmusp.citation.scopus | 3 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 |
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