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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MARTINS-FILHO, Sebastiao N. | |
dc.contributor.author | ALVES, Venancio A. F. | |
dc.contributor.author | WAKAMATSU, Alda | |
dc.contributor.author | MAEDA, Miho | |
dc.contributor.author | CRAIG, Amanda J. | |
dc.contributor.author | ASSATO, Aline K. | |
dc.contributor.author | VILLACORTA-MARTIN, Carlos | |
dc.contributor.author | D'AVOLA, Delia | |
dc.contributor.author | LABGAA, Ismail | |
dc.contributor.author | CARRILHO, Flair J. | |
dc.contributor.author | THUNG, Swan N. | |
dc.contributor.author | VILLANUEVA, Augusto | |
dc.date.accessioned | 2019-05-30T13:38:45Z | |
dc.date.available | 2019-05-30T13:38:45Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | HISTOPATHOLOGY, v.74, n.5, p.718-730, 2019 | |
dc.identifier.issn | 0309-0167 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/31824 | |
dc.description.abstract | Aims Access to tissue in patients with hepatocellular carcinoma (HCC) is limited compared to other malignancies, particularly at advanced stages. This has precluded a thorough characterisation of molecular drivers of HCC dissemination, particularly in relation to distant metastases. Biomarker assessment is restricted to early stages, and paired primary-metastatic comparisons between samples from the same patient are difficult. Methods and results We report the evaluation of 88 patients with HCC who underwent autopsy, including multiregional sampling of primary and metastatic sites totalling 230 nodules analysed. The study included morphological assessment, immunohistochemistry and mutation status of the TERT promoter, the most frequently mutated gene in HCC. We confirm a strong predilection of HCC for lung dissemination, including subclinical micrometastases (unrecognised during imaging and macroscopic examinations) in 30% of patients with disseminated disease. Size of dominant tumour nodule; multinodularity; macrovascular invasion; high histological, nuclear and architectural grades; and cellular crowding were associated with the presence of extrahepatic metastasis. Among the immunohistochemistry markers tested, metastatic nodules had significantly higher K19 and EpCAM expression than primary liver tumours. Morphological and immunohistochemical features showed that metastatic HCC could be traced back to the primary tumour, sometimes to a specific hepatic nodule. Conclusions This study suggests limited heterogeneity in metastatic sites compared to primary tumour sites. | eng |
dc.description.sponsorship | CAPES doctorate grant | |
dc.description.sponsorship | Terry Fox Foundation Fellowship Award | |
dc.description.sponsorship | Alan Hofmann Clinical and Translational Research Award | |
dc.description.sponsorship | US Department of Defense [CA150272P3] | |
dc.description.sponsorship | Tisch Cancer Institute (Cancer Center Grant) [P30 CA196521] | |
dc.language.iso | eng | |
dc.publisher | WILEY | eng |
dc.relation.ispartof | Histopathology | |
dc.rights | restrictedAccess | eng |
dc.subject | extra-hepatic metastasis | eng |
dc.subject | hepatocellular carcinoma | eng |
dc.subject | tumor heterogeneity | eng |
dc.subject.other | intratumor heterogeneity | eng |
dc.subject.other | keratin 19 | eng |
dc.subject.other | tissue microarrays | eng |
dc.subject.other | cancer | eng |
dc.subject.other | expression | eng |
dc.subject.other | grade | eng |
dc.subject.other | liver | eng |
dc.subject.other | immunohistochemistry | eng |
dc.subject.other | mutations | eng |
dc.subject.other | prognosis | eng |
dc.title | A phenotypical map of disseminated hepatocellular carcinoma suggests clonal constraints in metastatic sites | eng |
dc.type | article | eng |
dc.rights.holder | Copyright WILEY | eng |
dc.identifier.doi | 10.1111/his.13809 | |
dc.identifier.pmid | 30636011 | |
dc.subject.wos | Cell Biology | eng |
dc.subject.wos | Pathology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | MAEDA, Miho:Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, Liver Canc Res Program,Div Liver Dis, New York, NY 10029 USA | |
hcfmusp.author.external | CRAIG, Amanda J.:Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, Liver Canc Res Program,Div Liver Dis, New York, NY 10029 USA | |
hcfmusp.author.external | VILLACORTA-MARTIN, Carlos:Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, Liver Canc Res Program,Div Liver Dis, New York, NY 10029 USA | |
hcfmusp.author.external | D'AVOLA, Delia:Clin Univ Navarra, Liver Unit, Ctr Invest Biomed Red Area Temat Enfermedades Hea, Pamplona, Spain | |
hcfmusp.author.external | LABGAA, Ismail:Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, Liver Canc Res Program,Div Liver Dis, New York, NY 10029 USA; Lausanne Univ Hosp CHUV, Dept Visceral Surg, Lausanne, Switzerland | |
hcfmusp.author.external | THUNG, Swan N.:Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA | |
hcfmusp.author.external | VILLANUEVA, Augusto:Icahn Sch Med Mt Sinai, Dept Med, Tisch Canc Inst, Liver Canc Res Program,Div Liver Dis, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Med, Div Hematol & Med Oncol, New York, NY 10029 USA | |
hcfmusp.description.beginpage | 718 | |
hcfmusp.description.endpage | 730 | |
hcfmusp.description.issue | 5 | |
hcfmusp.description.volume | 74 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000461886400005 | |
hcfmusp.origem.id | 2-s2.0-85063077855 | |
hcfmusp.publisher.city | HOBOKEN | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1365-2559 | |
hcfmusp.citation.scopus | 5 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/07 Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - ODS/03 |
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