The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids
Carregando...
Citações na Scopus
100
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Autores
Citação
PHARMACOLOGICAL RESEARCH, v.141, p.366-377, 2019
Resumo
The bacteria community living in the gut maintains a symbiotic relationship with the host and its unbalance has been associated with progression of a wide range of intestinal and extra intestinal conditions. Hypertension and chronic kidney disease (CKD) are closely associated diseases with high incidence rates all over the world. Increasing data have supported the involvement of gut microbiome in the blood pressure regulation and the impairment of CKD prognosis. In hypertension, the reduced number of short-chain fatty acids (SCFAs) producing bacteria is associated with modifications in gut environment, involving reduction of the hypoxic gut profile and worsening of the microbial balance, leading to a loss of epithelial barrier integrity, development of gut inflammation and the reduction of SCFAs plasma levels. These modifications compromise the blood pressure regulation and, as a consequence, favor the end organ damage, also affecting the kidneys. In CKD, impaired renal function leads to accumulation of high levels of uremic toxins that reach the intestine and cause alterations in bacteria composition and fecal metabolite profile, inducing a positive feedback that allows translocation of endotoxins into the bloodstream, which enhances local kidney inflammation and exacerbate kidney injury, compromising even more CKD prognosis. In line with these data, the use of prebiotics, probiotics and fecal microbiota transplantation are becoming efficient therapies to improve the gut dysbiosis aiming hypertension and CKD treatment. This review describes how changes in gut microbiota composition can affect the development of hypertension and the progression of kidney diseases, highlighting the importance of the gut microbial composition uncovering to improve human health maintenance and, especially, for the development of new alternative therapies.
Palavras-chave
Hypertension, Chronic kidney disease, Inflammation, Gut microbiota, Short chain fatty acids
Referências
- Aagaard K, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3008599
- Adam A, 2001, J NUTR, V131, P1770
- Ahren IL, 2015, CLIN NUTR, V34, P719, DOI 10.1016/j.clnu.2014.08.009
- Allison SD, 2008, P NATL ACAD SCI USA, V105, P11512, DOI 10.1073/pnas.0801925105
- Andersen K, 2017, J AM SOC NEPHROL, V28, P76, DOI 10.1681/ASN.2015111285
- Andrade-Oliveira V, 2015, J AM SOC NEPHROL, V26, P1877, DOI 10.1681/ASN.2014030288
- Backhed F, 2015, CELL HOST MICROBE, V17, P852, DOI 10.1016/j.chom.2015.05.012
- BAEZ S, 1971, J EXP MED, V134, P846, DOI 10.1084/jem.134.4.846
- Barton W, 2018, GUT, V67, P625, DOI 10.1136/gutjnl-2016-313627
- Bergmann KR, 2013, AM J PATHOL, V182, P1595, DOI 10.1016/j.ajpath.2013.01.013
- Bier A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091154
- Bloemen JG, 2009, CLIN NUTR, V28, P657, DOI 10.1016/j.clnu.2009.05.011
- Bolognini D, 2016, MOL PHARMACOL, V89, P388, DOI 10.1124/mol.115.102301
- Bossola M, 2009, CLIN J AM SOC NEPHRO, V4, P379, DOI 10.2215/CJN.03490708
- Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
- Brown JM, 2018, NAT REV MICROBIOL, V16, P171, DOI 10.1038/nrmicro.2017.149
- Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191
- Carretero OA, 2000, CIRCULATION, V101, P329, DOI 10.1161/01.CIR.101.3.329
- Carvalho-Ramos II, 2018, J PEDIAT-BRAZIL, V94, P258, DOI 10.1016/j.jped.2017.05.013
- Chakraborty S, 2018, CELL REP, V25, P677, DOI 10.1016/j.celrep.2018.09.058
- Collins FS, 2004, NATURE, V431, P931, DOI 10.1038/nature03001
- Comte J, 2013, FRONT MICROBIOL, V4, DOI 10.3389/fmicb.2013.00112
- Coppa GV, 2004, J CLIN GASTROENTEROL, V38, pS80, DOI 10.1097/01.mcg.0000128926.14285.25
- Correa RO, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.17
- David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
- Davie JR, 2003, J NUTR, V133, p2485S, DOI 10.1093/jn/133.7.2485S
- De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
- den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
- Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
- Dethlefsen L, 2007, NATURE, V449, P811, DOI 10.1038/nature06245
- Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
- Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
- Duncan SH, 2004, BRIT J NUTR, V91, P915, DOI 10.1079/BJN20041150
- Perez-Cobas AE, 2013, GUT, V62, P1591, DOI [10.4161/gmic.27128, 10.1136/gutjnl-2012-303184]
- Evans P.D., 2011, MEDICINE, V39, P402
- Faith JJ, 2013, SCIENCE, V341, P44, DOI 10.1126/science.1237439
- Felizardo RJF, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.36
- Flint Harry J, 2012, Gut Microbes, V3, P289, DOI 10.4161/gmic.19897
- Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
- Fujimura KE, 2016, NAT MED, V22, P1187, DOI 10.1038/nm.4176
- Fujimura KE, 2014, P NATL ACAD SCI USA, V111, P805, DOI 10.1073/pnas.1310750111
- Galla S, 2018, PHYSIOL GENOMICS, V50, P837, DOI 10.1152/physiolgenomics.00073.2018
- Gao B, 2017, BMC PHARMACOL TOXICO, V18, DOI 10.1186/s40360-017-0150-9
- Ge HF, 2008, ENDOCRINOLOGY, V149, P4519, DOI 10.1210/en.2008-0059
- Gerritsen J, 2011, GENES NUTR, V6, P209, DOI 10.1007/s12263-011-0229-7
- Gomez-Guzman M, 2015, MOL NUTR FOOD RES, V59, P2326, DOI 10.1002/mnfr.201500290
- Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
- Graf Daniela, 2015, Microbial Ecology in Health and Disease, V26, P26164, DOI 10.3402/mehd.v26.26164
- Guarner F, 2003, LANCET, V361, P512, DOI 10.1016/S0140-6736(03)12489-0
- Hara T, 2013, REV PHYSIOL BIOCH P, V164, P77, DOI 10.1007/112_2013_13
- Harrison DG, 2013, J AM SOC HYPERTENS, V7, P68, DOI 10.1016/j.jash.2012.11.007
- HATCH M, 1994, J AM SOC NEPHROL, V5, P1339
- HATCH M, 1994, CLIN SCI, V86, P511, DOI 10.1042/cs0860511
- Hatch M, 2013, UROLITHIASIS, V41, P379, DOI 10.1007/s00240-013-0601-8
- Hocher B, 2017, NAT REV NEPHROL, V13, P269, DOI 10.1038/nrneph.2017.30
- Holmes AJ, 2017, CELL METAB, V25, P140, DOI 10.1016/j.cmet.2016.10.021
- Holzapfel WH, 1998, INT J FOOD MICROBIOL, V41, P85, DOI 10.1016/S0168-1605(98)00044-0
- Hughes-Large JM, 2014, ATHEROSCLEROSIS, V237, P696, DOI 10.1016/j.atherosclerosis.2014.10.090
- Huttenhower C, 2012, NATURE, V486, P207, DOI 10.1038/nature11234
- Ichii O, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108448
- Jang HR, 2009, AM J PHYSIOL-RENAL, V297, pF1457, DOI 10.1152/ajprenal.90769.2008
- Jimenez E, 2005, CURR MICROBIOL, V51, P270, DOI 10.1007/s00284-005-0020-3
- Jimenez E, 2008, RES MICROBIOL, V159, P187, DOI 10.1016/j.resmic.2007.12.007
- Johnson RJ, 2005, J AM SOC NEPHROL, V16, P1909, DOI 10.1681/ASN.2005010063
- Karbach SH, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003698
- Keddis MT, 2012, MAYO CLIN PROC, V87, P1046, DOI 10.1016/j.mayocp.2012.05.025
- Khalesi S, 2014, HYPERTENSION, V64, P897, DOI 10.1161/HYPERTENSIONAHA.114.03469
- Kim A, 2015, J CLIN GASTROENTEROL, V49, pS20, DOI 10.1097/MCG.0000000000000356
- Kim S, 2018, CLIN SCI, V132, P701, DOI [10.1042/cs20180087, 10.1042/CS20180087]
- Kimura I, 2011, P NATL ACAD SCI USA, V108, P8030, DOI 10.1073/pnas.1016088108
- Kobayashi N, 2002, NEPHRON, V91, P480, DOI 10.1159/000064291
- Koenig JE, 2011, P NATL ACAD SCI USA, V108, P4578, DOI 10.1073/pnas.1000081107
- Koppe L, 2015, KIDNEY INT, V88, P958, DOI 10.1038/ki.2015.255
- Kostylina G, 2008, CELL DEATH DIFFER, V15, P134, DOI 10.1038/sj.cdd.4402238
- Krishnamurthy VMR, 2012, KIDNEY INT, V81, P300, DOI 10.1038/ki.2011.355
- Le Poul E, 2003, J BIOL CHEM, V278, P25481, DOI 10.1074/jbc.M301403200
- Lee YK, 2010, SCIENCE, V330, P1768, DOI 10.1126/science.1195568
- Li J, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0222-x
- Li JH, 2014, NAT BIOTECHNOL, V32, P834, DOI 10.1038/nbt.2942
- Li QR, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00120
- Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
- Lyte M, 2014, ADV EXP MED BIOL, V817, P3, DOI 10.1007/978-1-4939-0897-4_1
- MACFARLANE GT, 1992, J APPL BACTERIOL, V72, P57, DOI 10.1111/j.1365-2672.1992.tb05187.x
- Machiels K, 2014, GUT, V63, P1275, DOI 10.1136/gutjnl-2013-304833
- Macpherson AJ, 2001, MICROBES INFECT, V3, P1021, DOI 10.1016/S1286-4579(01)01460-5
- Marino E, 2017, NAT IMMUNOL, V18, P552, DOI 10.1038/ni.3713
- Marques FZ, 2017, CIRCULATION, V135, P964, DOI 10.1161/CIRCULATIONAHA.116.024545
- Martin V, 2012, J HUM LACT, V28, P36, DOI 10.1177/0890334411424729
- Masahata K, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4704
- Maurice CF, 2013, CELL, V152, P39, DOI 10.1016/j.cell.2012.10.052
- Meijers BKI, 2010, NEPHROL DIAL TRANSPL, V25, P219, DOI 10.1093/ndt/gfp414
- Mell B, 2015, PHYSIOL GENOMICS, V47, P187, DOI 10.1152/physiolgenomics.00136.2014
- Miller TL, 1996, APPL ENVIRON MICROB, V62, P1589
- Miura K, 2004, AM J EPIDEMIOL, V159, P572, DOI 10.1093/aje/kwh085
- Monhart V, 2013, COR VASA, V55, pE397, DOI 10.1016/j.crvasa.2013.07.006
- Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
- MORTENSEN FV, 1994, PHARMACOL TOXICOL, V75, P181, DOI 10.1111/j.1600-0773.1994.tb00344.x
- Motojima M, 2003, KIDNEY INT, V63, P1671, DOI 10.1046/j.1523-1755.2003.00906.x
- Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
- Mullane KM, 2013, AM J NEPHROL, V38, P1, DOI 10.1159/000351757
- Muntner P, 2010, AM J KIDNEY DIS, V55, P441, DOI 10.1053/j.ajkd.2009.09.014
- Natarajan N, 2016, PHYSIOL GENOMICS, V48, P826, DOI 10.1152/physiolgenomics.00089.2016
- NIWA T, 1994, AM J NEPHROL, V14, P207, DOI 10.1159/000168716
- Omenetti S, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00639
- Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
- Pirkle JL, 2013, MINERVA UROL NEFROL, V65, P37
- Pluznick JL, 2013, P NATL ACAD SCI USA, V110, P4410, DOI 10.1073/pnas.1215927110
- Pluznick JL, 2009, P NATL ACAD SCI USA, V106, P2059, DOI 10.1073/pnas.0812859106
- Poesen R, 2016, J AM SOC NEPHROL, V27, P1389, DOI 10.1681/ASN.2015030279
- Ravera M, 2006, J AM SOC NEPHROL, V17, pS98, DOI 10.1681/ASN.2005121319
- Reese AT, 2018, NAT MICROBIOL, V3, P1441, DOI 10.1038/s41564-018-0267-7
- Rooks MG, 2016, NAT REV IMMUNOL, V16, P341, DOI 10.1038/nri.2016.42
- Rossi M, 2016, CLIN J AM SOC NEPHRO, V11, P223, DOI 10.2215/CJN.05240515
- Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
- Santisteban MM, 2017, CIRC RES, V120, P312, DOI 10.1161/CIRCRESAHA.116.309006
- Saran R., 2018, USRDS ANN DATA REPOR
- Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
- Sharaf El Din Usama Abdel Azim, 2016, World J Nephrol, V5, P258, DOI 10.5527/wjn.v5.i3.258
- Shi KH, 2014, DIGEST DIS SCI, V59, P2109, DOI 10.1007/s10620-014-3202-7
- Siener R, 2013, KIDNEY INT, V83, P1144, DOI 10.1038/ki.2013.104
- Sirich TL, 2014, CLIN J AM SOC NEPHRO, V9, P1603, DOI 10.2215/CJN.00490114
- Sleator RD, 2010, MED HYPOTHESES, V74, P214, DOI 10.1016/j.mehy.2009.08.047
- Sommer F, 2013, NAT REV MICROBIOL, V11, P227, DOI 10.1038/nrmicro2974
- Stevens PE, 2013, ANN INTERN MED, V158, P825, DOI 10.7326/0003-4819-158-11-201306040-00007
- Stripling J, 2015, OPEN FORUM INFECT DI, V2, DOI 10.1093/ofid/ofv078
- Suez J., 2018, CELL, V174, DOI [10.1016/j.cell.2018.08.047 e16, DOI 10.1016/J.CELL.2018.08.047E16]
- Suez J, 2018, CELL, V174, P1406, DOI 10.1016/j.cell.2018.08.047
- Sun CY, 2012, KIDNEY INT, V81, P640, DOI 10.1038/ki.2011.445
- Suryavanshi MV, 2016, SCI REP-UK, V6, DOI 10.1038/srep34712
- Suzuki T, 2008, BRIT J NUTR, V100, P297, DOI 10.1017/S0007114508888733
- Tazoe H, 2009, BIOMED RES-TOKYO, V30, P149, DOI 10.2220/biomedres.30.149
- Tedla FM, 2011, INT J HYPERTENS, DOI 10.4061/2011/132405
- Thangaraju M, 2009, CANCER RES, V69, P2826, DOI 10.1158/0008-5472.CAN-08-4466
- Tuomilehto J, 2004, J HUM HYPERTENS, V18, P795, DOI 10.1038/sj.jhh.1001745
- Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
- Vaziri ND, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114881
- Vaziri ND, 2013, AM J NEPHROL, V37, P1, DOI 10.1159/000345969
- Vaziri ND, 2013, KIDNEY INT, V83, P308, DOI 10.1038/ki.2012.345
- Vinolo MAR, 2011, NUTRIENTS, V3, P858, DOI 10.3390/nu3100858
- Waghulde H, 2018, HYPERTENSION, V72, P1125, DOI 10.1161/HYPERTENSIONAHA.118.11175
- Wanders D, 2012, BIOCHEM BIOPH RES CO, V425, P278, DOI 10.1016/j.bbrc.2012.07.082
- Wang FQ, 2012, NEPHROLOGY, V17, P733, DOI 10.1111/j.1440-1797.2012.01647.x
- Wang X, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4490
- Wen L, 2008, NATURE, V455, P1109, DOI 10.1038/nature07336
- Wilck N, 2017, NATURE, V551, P585, DOI 10.1038/nature24628
- Wilson M., 2005, ROLE INDIGENOUS MICR, P375
- Wong J, 2014, AM J NEPHROL, V39, P230, DOI 10.1159/000360010
- Wu B, 2017, NEPHRON, V135, P156, DOI 10.1159/000452453
- Xiong YM, 2004, P NATL ACAD SCI USA, V101, P1045, DOI 10.1073/pnas.2637002100
- Xu H, 2017, CLIN J AM SOC NEPHRO, V12, P1399, DOI 10.2215/CJN.00250117
- Yang GL, 2015, MICROB CELL FACT, V14, DOI 10.1186/s12934-015-0394-2
- Yang T, 2015, HYPERTENSION, V65, P1331, DOI 10.1161/HYPERTENSIONAHA.115.05315
- Yang X, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006074
- Zhou B, 2017, LANCET, V389, P37, DOI 10.1016/S0140-6736(16)31919-5
- Zhou T, 2016, J PHYSIOL-LONDON, V594, P4225, DOI 10.1113/JP271936
- ZWEIFACH BW, 1958, J EXP MED, V107, P437, DOI 10.1084/jem.107.3.437