Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat

Imagem de Miniatura
Arquivos
art_BATISTA_Characterization_of_traumatic_spinal_cord_injury_model_in_2019.PDF (1.9 MB)
Citações na Scopus
Tipo de produção
article
Data de publicação
2019
DOI
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS LTD
Autores
DALE, Camila Squarzoni
MORGALLA, Matthias
Citação
SOMATOSENSORY AND MOTOR RESEARCH, v.36, n.1, p.14-23, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of the severity of this condition and the absence of effective treatments, the establishment of a reliable animal model that reproduces neuropathic pain after injury is crucial for a better understanding of the pathophysiology and for the development of new therapeutic strategies. Thus, the objective of the present study was to standardize the traumatic SCI model in relation to neuropathic pain.Materials and methods: Wistar rats were submitted to SCI of mild intensity (pendulum height 12.5mm) or moderate intensity (pendulum height 25mm) using the New York University Impactor equipment. Behavioural assessment was performed during 8weeks. Thereafter, spinal cords were processed for immunohistochemistry.Results: The animals of the moderate injury group in comparison with mild injury had a greater motor function deficit, worse mechanical allodynia, and latter bladder recovery; moreover, histological analysis revealed more extensive lesions with lower neuronal population.Conclusions: Our study suggests that moderate SCI causes a progressive and long-lasting painful condition (at least 8weeks), in addition to motor impairment, and thus represents a reliable animal model for the study of chronic neuropathic pain after SCI.
Palavras-chave
Spinal cord injuries, chronic pain, hyperalgesia, animal experimentation, rats Wistar
URI
https://observatorio.fm.usp.br/handle/OPI/32504
Referências
  1. Ahmed MM, 2014, ANN NEUROSCI, V21, P97, DOI 10.5214/ans.0972.7531.210305
  2. Andresen SR, 2016, SPINAL CORD, V54, P973, DOI 10.1038/sc.2016.46
  3. Baastrup C, 2008, CNS DRUGS, V22, P455, DOI 10.2165/00023210-200822060-00002
  4. Baastrup C, 2010, PAIN, V151, P670, DOI 10.1016/j.pain.2010.08.024
  5. Baron R, 2000, CLIN J PAIN, V16, pS12, DOI 10.1097/00002508-200006001-00004
  6. Basso DM, 1996, J NEUROTRAUM, V13, P343, DOI 10.1089/neu.1996.13.343
  7. Brown A, 2012, EXP NEUROL, V235, P133, DOI 10.1016/j.expneurol.2011.11.004
  8. Bruce JC, 2002, EXP NEUROL, V178, P33, DOI 10.1006/exnr.2002.8026
  9. BUNGE RP, 1993, ADV NEUROL, V59, P75
  10. Bunge RP, 1994, NEUROBIOLOGY CENTRAL, P328
  11. Burke D, 2018, EUR J PAIN, V22, P1662, DOI 10.1002/ejp.1248
  12. Cairns DM, 1996, ARCH PHYS MED REHAB, V77, P329, DOI 10.1016/S0003-9993(96)90079-9
  13. Calmels P., 2009, Annals of Physical and Rehabilitation Medicine, V52, P83, DOI 10.1016/j.rehab.2008.12.012
  14. CHAPLAN SR, 1994, J NEUROSCI METH, V53, P55, DOI 10.1016/0165-0270(94)90144-9
  15. Cheriyan T, 2014, SPINAL CORD, V52, P588, DOI 10.1038/sc.2014.91
  16. Chhaya SJ, 2019, J NEUROTRAUM, V36, P877, DOI 10.1089/neu.2018.5819
  17. Christensen MD, 1997, J NEUROTRAUM, V14, P517, DOI 10.1089/neu.1997.14.517
  18. Christensen MD, 1996, PAIN, V68, P97, DOI 10.1016/S0304-3959(96)03224-1
  19. Coronel MF, 2016, J NEUROIMMUNOL, V292, P85, DOI 10.1016/j.jneuroim.2016.01.011
  20. Dale CS, 2006, PEPTIDES, V27, P2794, DOI 10.1016/j.peptides.2006.07.002
  21. Detloff MR, 2016, NEUROREHAB NEURAL RE, V30, P685, DOI 10.1177/1545968315619698
  22. Detloff MR, 2014, EXP NEUROL, V255, P38, DOI 10.1016/j.expneurol.2014.02.013
  23. Deuis JR, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00284
  24. Dugan EA, 2015, J NEUROTRAUM, V32, P622, DOI 10.1089/neu.2014.3692
  25. Eide PK, 1998, SPINAL CORD, V36, P601, DOI 10.1038/sj.sc.3100737
  26. Falnikar A, 2016, GLIA, V64, P396, DOI 10.1002/glia.22936
  27. Forner S, 2016, NEUROSCI LETT, V617, P14, DOI 10.1016/j.neulet.2016.02.005
  28. Fuchs PN, 2012, J INTEGR NEUROSCI, V11, P61, DOI 10.1142/S0219635212500045
  29. Furlanetti LL, 2015, NEUROREHAB NEURAL RE, V29, P1001, DOI 10.1177/1545968315581419
  30. Gaudet AD, 2017, EXP NEUROL, V295, P46, DOI 10.1016/j.expneurol.2017.05.011
  31. Gilron I, 2015, MAYO CLIN PROC, V90, P532, DOI 10.1016/j.mayocp.2015.01.018
  32. GRUNER JA, 1992, J NEUROTRAUM, V9, P123, DOI 10.1089/neu.1992.9.123
  33. Guan Y, 2012, CURR PAIN HEADACHE R, V16, P217, DOI 10.1007/s11916-012-0260-4
  34. Gwak YS, 2008, PAIN, V138, P410, DOI 10.1016/j.pain.2008.01.021
  35. Gwak YS, 2017, NEURAL PLAST, V2017, P1
  36. Hearn JH, 2019, ARCH PHYS MED REHAB, V100, P17, DOI 10.1016/j.apmr.2018.08.182
  37. Holtz KA, 2017, ARCH PHYS MED REHAB, V98, P1132, DOI 10.1016/j.apmr.2016.09.124
  38. Hulsebosch CE, 2000, J NEUROTRAUM, V17, P1205, DOI 10.1089/neu.2000.17.1205
  39. Hwang I, 2016, CELL TRANSPLANT, V25, P593, DOI 10.3727/096368915X689460
  40. Kato K, 2015, J NEUROL SCI, V355, P79, DOI 10.1016/j.jns.2015.05.024
  41. Kramer JLK, 2017, J NEUROSCI RES, V95, P1295, DOI 10.1002/jnr.23881
  42. Krassioukov AV, 2007, J REHABIL RES DEV, V44, P103, DOI 10.1682/JRRD.2005.10.0159
  43. Langford DJ, 2010, NAT METHODS, V7, P447, DOI [10.1038/NMETH.1455, 10.1038/nmeth.1455]
  44. Lee-Kubli CA, 2016, EXP NEUROL, V278, P91, DOI 10.1016/j.expneurol.2016.01.009
  45. Lindsay SL, 2017, GLIA, V65, P639, DOI 10.1002/glia.23117
  46. Luedtke K, 2014, J NEUROTRAUM, V31, P1107, DOI 10.1089/neu.2013.3204
  47. Lv Y, 2017, CAN J PHYSIOL PHARM, V95, P1389, DOI 10.1139/cjpp-2016-0528
  48. Majedi H, 2018, NEUROSCIENCES, V23, P292, DOI 10.17712/nsj.2018.4.20180223
  49. Maldonado-Bouchard S, 2016, BRAIN BEHAV IMMUN, V51, P176, DOI 10.1016/j.bbi.2015.08.009
  50. Martini AC, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0540-8
  51. Mehta Swati, 2015, Top Spinal Cord Inj Rehabil, V21, P166, DOI 10.1310/sci2102-166
  52. Miranpuri GS, 2016, ANN NEUROSCI, V23, P25, DOI 10.1159/000443553
  53. Mothe AJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10987-7
  54. Muller R, 2017, J REHABIL MED, V49, P489, DOI 10.2340/16501977-2241
  55. Nagoshi N, 2016, SPINAL CORD, V54, P656, DOI 10.1038/sc.2015.210
  56. Nasirinezhad F, 2016, J SPINAL CORD MED, V39, P212, DOI 10.1179/2045772315Y.0000000047
  57. Nasirinezhad F, 2015, MOL PAIN, V11, DOI 10.1186/1744-8069-11-2
  58. Nees TA, 2016, PAIN, V157, P687, DOI 10.1097/j.pain.0000000000000422
  59. NSCISC, 2018, NAT SPIN CORD INJ ST
  60. Park J, 2018, J CONTROL RELEASE, V290, P88, DOI 10.1016/j.jconrel.2018.10.003
  61. Previnaire J-G., 2009, Annals of Physical and Rehabilitation Medicine, V52, P188, DOI 10.1016/j.rehab.2008.12.002
  62. Putatunda R, 2014, BRAIN RES, V1581, P64, DOI 10.1016/j.brainres.2014.05.003
  63. Rekand Tiina, 2012, Tidsskr Nor Laegeforen, V132, P974, DOI 10.4045/tidsskr.11.0794
  64. RIVLIN AS, 1978, SURG NEUROL, V10, P39
  65. Ruiz-Juretschke F, 2011, NEUROLOGIA, V26, P26, DOI 10.1016/j.nrl.2010.10.003
  66. Sanchez-Brualla I, 2018, NEUROSCIENCE, V387, P48, DOI 10.1016/j.neuroscience.2017.08.033
  67. Saulino M, 2014, PHYS MED REH CLIN N, V25, P397, DOI 10.1016/j.pmr.2014.01.002
  68. Schneider LE, 2017, J NEUROTRAUM, V34, P2982, DOI 10.1089/neu.2016.4665
  69. Shaikh A, 2016, CAN J NEUROL SCI, V43, P311, DOI 10.1017/cjn.2015.321
  70. Shiao R, 2018, NEUROTHERAPEUTICS, V15, P635, DOI 10.1007/s13311-018-0633-4
  71. SIDDALL P, 1995, NEUROREPORT, V6, P1241, DOI 10.1097/00001756-199506090-00003
  72. Sjolund BH, 2002, BRAIN RES REV, V40, P250, DOI 10.1016/S0165-0173(02)00207-2
  73. Sliwinski C, 2018, J NEUROTRAUM, V35, P2222, DOI 10.1089/neu.2017.5431
  74. Teixeira MJ, 2013, ARQ NEURO-PSIQUIAT, V71, P600, DOI 10.1590/0004-282X20130103
  75. Tomycz L, 2014, J NEUROL SURG PART A, V75, P126, DOI 10.1055/s-0033-1349340
  76. Vanicky I, 2001, J NEUROTRAUM, V18, P1399, DOI 10.1089/08977150152725687
  77. Vardeh D, 2016, J PAIN, V17, pT50, DOI 10.1016/j.jpain.2016.03.001
  78. Woolf CJ, 1999, LANCET, V353, P1959, DOI 10.1016/S0140-6736(99)01307-0
  79. Wu JF, 2016, PAIN, V157, P488, DOI 10.1097/j.pain.0000000000000393
  80. Yaksh TL, 2017, CURR NEUROPHARMACOL, V15, P232, DOI 10.2174/1570159X14666160307145542
  81. YOUNG RF, 1994, ACT NEUR S, V62, P105
  82. Yousefifard M, 2016, STEM CELL RES THER, V7, DOI 10.1186/s13287-016-0295-2
  83. Zhao P, 2016, J NEUROPHYSIOL, V115, P2893, DOI 10.1152/jn.01057.2015

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOT
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - HC/IPq
Carregar mais