The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects

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art_BLANCO-VIEIRA_The_impact_of_attention_deficit_hyperactivity_disorder_in_2019.PDF (369.01 KB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
BLANCO-VIEIRA, Thiago
SANTOS, Matheus
FERRAO, Ygor A.
TORRES, Albina R.
BLOCH, Michael H.
LECKMAN, James F.
ROSARIO, Maria C. do
Citação
DEPRESSION AND ANXIETY, v.36, n.6, p.533-542, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Recent findings suggest an association between attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Thus, we evaluated the clinical associated features of ADHD in a large sample of adult OCD patients. Methods A cross-sectional study including 955 adult patients with OCD from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (C-TOC). Clinical characteristics in adult OCD patients with and without comorbid ADHD were compared using Fisher's exact test, t-tests or Mann-Whitney tests. Bivariate analyses were followed by logistic regression analysis to identify clinical characteristics independently associated with ADHD comorbidity. Results The lifetime prevalence of ADHD in adult OCD patients was 13.7%. The current results indicate that OCD + ADHD patients were more severe, had an earlier onset of the obsessive-compulsive symptoms, a higher history of rheumatic fever, with higher frequencies of sensory phenomena and comorbidity with Tourette syndrome. They also had an increased risk for academic impairment and suicide attempts. Conclusion Adult OCD patients with ADHD present some specific clinical features and may represent a special subgroup of adult OCD. Future studies should focus on the development of interventions more tailored to the phenotype of this subgroup of patients.
Palavras-chave
attention deficit disorder with hyperactivity, comorbidity, obsessive-compulsive disorder
URI
https://observatorio.fm.usp.br/handle/OPI/33173
Referências
  1. Abramovitch A, 2015, HARVARD REV PSYCHIAT, V23, P245, DOI 10.1097/HRP.0000000000000050
  2. Amat JA, 2006, AM J PSYCHIAT, V163, P1106, DOI 10.1176/appi.ajp.163.6.1106
  3. American Psychiatric Association, 1994, DIAGN STAT MAN MENT
  4. Angelakis I, 2015, CLIN PSYCHOL REV, V39, P1, DOI 10.1016/j.cpr.2015.03.002
  5. Anholt GE, 2010, J AUTISM DEV DISORD, V40, P580, DOI 10.1007/s10803-009-0922-1
  6. Beck AT, 1990, MANUAL BECK ANXIETY
  7. Beck AT, 1987, MANUAL REVISED BECK
  8. Brem S, 2014, ADHD-ATTEND DEFICIT, V6, P175, DOI 10.1007/s12402-014-0146-x
  9. Carlsson ML, 2001, PROG NEURO-PSYCHOPH, V25, P5, DOI 10.1016/S0278-5846(00)00146-9
  10. Coughlin CG, 2015, J CHILD ADOL PSYCHOP, V25, P611, DOI 10.1089/cap.2015.0075
  11. da Silva PH, 2008, CNS SPECTRUMS, V13, P425
  12. Dalsgaard S, 2015, LANCET, V385, P2190, DOI 10.1016/S0140-6736(14)61684-6
  13. de Alvarenga PG, 2012, CNS SPECTRUMS, V17, P87, DOI 10.1017/S1092852912000491
  14. Diniz JB, 2012, REV BRAS PSIQUIATR, V34, pS81, DOI 10.1016/S1516-4446(12)70056-9
  15. Eisen JL, 2013, J CLIN PSYCHIAT, V74, P233, DOI 10.4088/JCP.12m07657
  16. Eisen JL, 2006, COMPR PSYCHIAT, V47, P272, DOI 10.1016/j.comppsych.2005.11.006
  17. Erskine HE, 2016, J AM ACAD CHILD PSY, V55, P841, DOI 10.1016/j.jaac.2016.06.016
  18. FERNANDEZDELACRUZ, 2017, MOL PSYCHIATR, V22, P1626, DOI 10.1038/MP.2016.115
  19. Ferrao YA, 2012, PSYCHIAT RES, V197, P253, DOI 10.1016/j.psychres.2011.09.017
  20. First M. B., 2004, STRUCTURAL CLIN INTE
  21. First M. B., 1997, STRUCTURED CLIN INTE
  22. Franke B, 2018, EUR NEUROPSYCHOPHARM, V28, P1059, DOI 10.1016/j.euroneuro.2018.08.001
  23. Freeman RD, 2000, DEV MED CHILD NEUROL, V42, P436, DOI 10.1017/S0012162200000839
  24. Frost RO, 2011, DEPRESS ANXIETY, V28, P876, DOI 10.1002/da.20861
  25. Geller DA, 2001, J NERV MENT DIS, V189, P471, DOI 10.1097/00005053-200107000-00009
  26. Geller D, 2007, BIOL PSYCHIAT, V61, P316, DOI 10.1016/j.biopsych.2006.03.083
  27. Geller D, 2007, BIOL PSYCHIAT, V61, P1388, DOI 10.1016/j.biopsych.2006.09.026
  28. GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
  29. Gorenstein C, 1996, BRAZ J MED BIOL RES, V29, P453
  30. Gothelf D, 2007, INT J NEUROPSYCHOPH, V10, P301, DOI 10.1017/S1461145706006699
  31. Grevet EH, 2005, ARQ NEURO-PSIQUIAT, V63, P307, DOI 10.1590/S0004-282X2005000200019
  32. Ivarsson T, 2008, EUR CHILD ADOLES PSY, V17, P20, DOI 10.1007/s00787-007-0626-z
  33. Jaisoorya TS, 2003, EUR CHILD ADOLES PSY, V12, P290, DOI 10.1007/s00787-003-0342-2
  34. Jakubovski E, 2011, PROG NEURO-PSYCHOPH, V35, P1677, DOI 10.1016/j.pnpbp.2011.05.012
  35. Kano Y, 2015, COMPR PSYCHIAT, V62, P141, DOI 10.1016/j.comppsych.2015.07.006
  36. Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
  37. Kessler RC, 2005, PSYCHOL MED, V35, P245, DOI 10.1017/S0033291704002892
  38. Knopp J, 2013, CLIN PSYCHOL REV, V33, P1067, DOI 10.1016/j.cpr.2013.08.008
  39. LECKMAN JF, 1989, J AM ACAD CHILD PSY, V28, P566, DOI 10.1097/00004583-198907000-00015
  40. Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
  41. Mancebo MC, 2008, ACTA PSYCHIAT SCAND, V118, P149, DOI 10.1111/j.1600-0447.2008.01224.x
  42. Mann JJ, 2001, NEUROPSYCHOPHARMACOL, V24, P467, DOI 10.1016/S0893-133X(00)00228-1
  43. Masi G, 2006, COMPR PSYCHIAT, V47, P42, DOI 10.1016/j.comppsych.2005.04.008
  44. Masi G, 2010, PSYCHOPATHOLOGY, V43, P69, DOI 10.1159/000274175
  45. Mataix-Cols D, 2018, MOL PSYCHIATR, V23, P1652, DOI 10.1038/mp.2017.215
  46. Mathews CA, 2011, J AM ACAD CHILD PSY, V50, P46, DOI 10.1016/j.jaac.2010.10.004
  47. Mattos Paulo, 2006, Arch. Clin. Psychiatry (São Paulo), V33, P188, DOI 10.1590/S0101-60832006000400004
  48. Mersin Kilic S., 2016, J ATTENTION DISORDER
  49. Michaelovsky E, 2008, INT J NEUROPSYCHOPH, V11, P351, DOI 10.1017/S1461145707008085
  50. Miguel EC, 2000, J CLIN PSYCHIAT, V61, P150, DOI 10.4088/JCP.v61n0213
  51. Miguel EC, 2008, REV BRAS PSIQUIATR, V30, P185, DOI 10.1590/S1516-44462008000300003
  52. Nielsen PR, 2017, J AM ACAD CHILD PSY, V56, P234, DOI 10.1016/j.jaac.2016.12.010
  53. O'Rourke JA, 2011, AM J MED GENET B, V156B, P553, DOI 10.1002/ajmg.b.31195
  54. Perez-Vigil A, 2018, JAMA PSYCHIAT, V75, P47, DOI 10.1001/jamapsychiatry.2017.3523
  55. Pinto R, 2016, AM J MED GENET B, V171, P938, DOI 10.1002/ajmg.b.32436
  56. Rayappa S, 2017, EUR PSYCHIAT, V41, pS323, DOI 10.1016/j.eurpsy.2017.02.248
  57. Rizzo R, 2012, BRAIN DEV-JPN, V34, P667, DOI 10.1016/j.braindev.2011.11.006
  58. Robertson MM, 2009, J PSYCHOSOM RES, V67, P475, DOI 10.1016/j.jpsychores.2009.07.010
  59. Rosario MC, 2009, CNS SPECTRUMS, V14, P315, DOI 10.1017/S1092852900020319
  60. Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798
  61. Rubia K, 2011, HUM BRAIN MAPP, V32, P601, DOI 10.1002/hbm.21048
  62. Rubia K, 2010, HUM BRAIN MAPP, V31, P287, DOI 10.1002/hbm.20864
  63. Ruscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94
  64. Sciberras E, 2014, PEDIATRICS, V133, P801, DOI 10.1542/peds.2013-3686
  65. Sheppard B, 2010, DEPRESS ANXIETY, V27, P667, DOI 10.1002/da.20691
  66. Simon V, 2009, BRIT J PSYCHIAT, V194, P204, DOI 10.1192/bjp.bp.107.048827
  67. Swedo SE, 2012, PEDIAT THERAPEUT, V2, P113, DOI 10.4172/2161-0665.1000113
  68. Tolin DF, 2011, BEHAV RES THER, V49, P120, DOI 10.1016/j.brat.2010.12.002
  69. Torres AR, 2006, AM J PSYCHIAT, V163, P1978, DOI 10.1176/appi.ajp.163.11.1978
  70. Torres AR, 2011, J CLIN PSYCHIAT, V72, P17, DOI 10.4088/JCP.09m05651blu
  71. Velloso P, 2016, EUR PSYCHIAT, V38, P1, DOI 10.1016/j.eurpsy.2016.05.003
  72. Walitza S, 2008, J NEURAL TRANSM, V115, P187, DOI 10.1007/s00702-007-0841-2
  73. Wu MS, 2016, CLIN PSYCHOL REV, V45, P34, DOI 10.1016/j.cpr.2016.03.003

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - ODS/03