Steatosis and steatohepatitis found in adults after death due to non-burn trauma

Imagem de Miniatura
Arquivos
art_REIS-JUNIOR_Steatosis_and_steatohepatitis_found_in_adults_after_death_2019.PDF (940.9 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2019
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
REIS-JUNIOR, Paulo
BASAN, Natalia
Citação
CLINICS, v.74, article ID e1070, 8p, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVE: With the increasing prevalence of steatosis, the number of steatotic liver grafts from deceased donors is also increasing. Thus, determining the prevalence and the population risk factors of steatosis may assist in risk stratification. The aim of this study was to evaluate the prevalence and predictors of steatosis and steatohepatitis among livers from adults who died due to non-burn trauma. METHODS: Specimens were collected from 224 adults undergoing autopsy at a regional autopsy referral center from September 2011 to April 2013. Histopathological examination was performed on six samples obtained from different lobes of each liver. The outcomes of interest were the presence of steatosis, steatohepatitis, NASH inflammation and NASH fibrosis. The main predictors were body mass index, abdominal circumference, liver weight and volume, presence of cholelithiasis, and siderosis. Our modeling strategy made use of a series of generalized linear models with a binomial family. RESULTS: Our sample had a mean age of 40 years; steatosis was diagnosed in 48.2% of cases, and steatohepatitis was diagnosed in 2.7%. The presence of a high proportion of fatty changes was more prevalent among males and older individuals, with the most affected age group being 41-60 years. When evaluating the crude odds ratio for steatosis, the factors significantly associated with an increased risk of steatosis were greater abdominal circumference, BMI, and liver weight and the presence of siderosis. CONCLUSION: Our study reinforces the role of older age, obesity and hepatomegaly as predictors of fatty liver disease. These variables should be considered in the assessment of fatty changes in the livers of potential liver donors.
Palavras-chave
Steatosis, Steatohepatitis, Fatty Liver, Liver Disease, Authopsy
URI
https://observatorio.fm.usp.br/handle/OPI/35522
Referências
  1. Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
  2. Almeida AD, 2008, WORLD J GASTROENTERO, V14, P1415, DOI 10.3748/wjg.14.1415
  3. Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1056/NEJMra011775
  4. Attar BM, 2013, SCI WORLD J, DOI 10.1155/2013/481893
  5. Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
  6. Bonkovsky HL, 1999, J HEPATOL, V31, P421, DOI 10.1016/S0168-8278(99)80032-4
  7. Bonkovsky HL, 1996, SEMIN LIVER DIS, V16, P65, DOI 10.1055/s-2007-1007220
  8. Boppidi Hima, 2008, Postgrad Med, V120, pE01, DOI 10.3810/pgm.2008.07.1800
  9. Brunt EM, 2010, WORLD J GASTROENTERO, V16, P5286, DOI 10.3748/wjg.v16.i42.5286
  10. Cengiz M, 2014, INT J CLIN EXP MED, V7, P5453
  11. Clark JM, 2006, J CLIN GASTROENTEROL, V40, pS5
  12. Despres JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
  13. Deugnier Y, 2007, WORLD J GASTROENTERO, V13, P4755, DOI 10.3748/wjg.v13.i35.4755
  14. Fielding Cory M, 2014, Curr Hepatol Rep, V13, P151
  15. Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
  16. Frith J, 2009, GERONTOLOGY, V55, P607, DOI 10.1159/000235677
  17. Fujita N, 2011, ADV CLIN CHEM, V55, P105, DOI 10.1016/B978-0-12-387042-1.00006-X
  18. Galili T, 2015, BIOINFORMATICS, V31, P3718, DOI 10.1093/bioinformatics/btv428
  19. Gawrieh S, 2011, ANN DIAGN PATHOL, V15, P19, DOI 10.1016/j.anndiagpath.2010.08.001
  20. Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
  21. Ibrahim MA, 2013, LIFE SCI, V92, P114, DOI 10.1016/j.lfs.2012.11.004
  22. Kichian K, 2003, CAN J GASTROENTEROL, V17, P38, DOI 10.1155/2003/268528
  23. Kleiner DE, 2012, SEMIN LIVER DIS, V32, P3, DOI 10.1055/s-0032-1306421
  24. Kramer L, 2007, CRIT CARE MED, V35, P1099, DOI 10.1097/01.CCM.0000259462.97164.A0
  25. Kuhn M., 2016, APPL PREDICTIVE MODE, DOI [10.1007/978-1-4614-6849-3, DOI 10.1007/978-1-4614-6849-3]
  26. Lee PH, 2014, SCI REP-UK, V4, DOI 10.1038/srep06085
  27. Lee SS, 2014, WORLD J GASTROENTERO, V20, P7392, DOI 10.3748/wjg.v20.i23.7392
  28. Li H, 2009, HEPATOB PANCREAT DIS, V8, P377
  29. Luyckx FH, 1998, INT J OBESITY, V22, P222, DOI 10.1038/sj.ijo.0800571
  30. Machado MV, 2013, J HEPATOL, V58, P1007, DOI 10.1016/j.jhep.2012.11.021
  31. Maher Jacquelyn J, 2002, Semin Gastrointest Dis, V13, P31
  32. Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
  33. MARTINS Aline M. A., 2013, Arq. Gastroenterol., V50, P15, DOI 10.1590/S0004-28032013000100004
  34. Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
  35. McCormack L, 2011, J HEPATOL, V54, P1055, DOI 10.1016/j.jhep.2010.11.004
  36. Mehta K, 2002, NUTR REV, V60, P289, DOI 10.1301/002966402320387224
  37. Merriman RB, 2006, HEPATOLOGY, V44, P874, DOI 10.1002/hep.21346
  38. Mottin CC, 2004, OBES SURG, V14, P635, DOI 10.1381/096089204323093408
  39. Obika M, 2012, EXP DIABETES RES, DOI 10.1155/2012/145754
  40. Oliveira CPMS, 2002, J CELL MOL MED, V6, P399, DOI 10.1111/j.1582-4934.2002.tb00518.x
  41. PAATERO P, 1994, ENVIRONMETRICS, V5, P111, DOI 10.1002/env.3170050203
  42. Pagadala MR, 2012, AM J GASTROENTEROL, V107, P1859, DOI 10.1038/ajg.2012.320
  43. Park SH, 2006, J GASTROEN HEPATOL, V21, P138, DOI 10.1111/j.1440-1746.2005.04086.x
  44. Rafiq N, 2008, SEMIN LIVER DIS, V28, P427, DOI 10.1055/s-0028-1091986
  45. Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084
  46. Reshef DN, 2011, SCIENCE, V334, P1518, DOI 10.1126/science.1205438
  47. Sandesc D, 2015, J CRIT CARE MED, V1, P81, DOI 10.1515/jccm-2015-0013
  48. Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
  49. Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
  50. Uchil Deepa, 2009, J Assoc Physicians India, V57, P201
  51. Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
  52. Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
  53. Vilgrain V, 2013, Diagn Interv Imaging, V94, P713, DOI 10.1016/j.diii.2013.03.010
  54. von Elm E, 2007, PREV MED, V45, P247, DOI 10.1016/j.ypmed.2007.08.012
  55. WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
  56. Wree A, 2013, NAT REV GASTRO HEPAT, V10, P627, DOI 10.1038/nrgastro.2013.149
  57. Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
  58. Yki-Jarvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
  59. Zezos P, 2014, WORLD J GASTROENTERO, V20, P15532, DOI 10.3748/wjg.v20.i42.15532
  60. Zois CD, 2010, WORLD J GASTROENTERO, V16, P3944, DOI 10.3748/wjg.v16.i31.3944

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - LIM/37
Artigos e Materiais de Revistas Científicas - ODS/03