Impact of neoadjuvant chemotherapy on surgical and pathological results of gastric cancer patients: A case-control study

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art_CHARRUF_Impact_of_neoadjuvant_chemotherapy_on_surgical_and_pathological_2020.PDF (1.27 MB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
Citação
JOURNAL OF SURGICAL ONCOLOGY, v.121, n.5, p.833-839, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and Objective Neoadjuvant chemotherapy (NACT) followed by radical surgery represents a treatment option for patients with advanced gastric cancer (GC). This case-control study aimed to evaluate the clinicopathological characteristics and surgical outcomes of GC patients who received NACT, and its impact on survival. Methods We retrospectively reviewed all patients with GC who underwent gastrectomy. A total of 45 cases with NACT were matched with consecutive 45 patients who underwent upfront gastrectomy for the following characteristics: gender, age, gastrectomy type, lymphadenectomy extent, American Society of Anesthesiologists class, histological type, cT and cN. Results NACT group had smaller tumors (4.9 vs 6.8 cm P = .006), lower lymphatic invasion rate (40% vs 73.3%, P = .001), lower venous invasion rate (18% vs 46.7%, P = .003) and lower perineural invasion rate (35% vs 77.8%, P < .0001). The ypTNM stage was lower in patients treated with NACT (P < .001). The major postoperative complication (POC) rate was lower in NACT patients (6.7% vs 24.4%, P = .02), as was hospital length of stay (10.8 vs 17 days, P = .005). Conclusions NACT allowed nodal and tumor downstaging. In addition, patients who underwent NACT had fewer POC and shorter length of hospital stay.
Palavras-chave
complications, gastric cancer, neoadjuvant chemotherapy, survival, tumor regression
URI
https://observatorio.fm.usp.br/handle/OPI/35947
Referências
  1. Al-Batran SE, 2019, LANCET, V393, P1948, DOI 10.1016/S0140-6736(18)32557-1
  2. Allum WH, 2011, GUT, V60, P1449, DOI 10.1136/gut.2010.228254
  3. Amin MB, 2016, AJCC CANC STAGING MA
  4. Berlth F, 2017, TRANSL GASTROENT HEP, V2, DOI 10.21037/tgh.2017.01.08
  5. Clavien PA, 2009, ANN SURG, V250, P187, DOI 10.1097/SLA.0b013e3181b13ca2
  6. Cunningham D, 2006, NEW ENGL J MED, V355, P11, DOI 10.1056/NEJMoa055531
  7. De Manzoni G, 2017, GASTRIC CANCER, V20, P20, DOI 10.1007/s10120-016-0615-3
  8. Degiuli M, 2014, BRIT J SURG, V101, P23, DOI 10.1002/bjs.9345
  9. Dias AR, 2016, GASTRIC CANCER, V19, P136, DOI 10.1007/s10120-014-0443-2
  10. Fujitani K, 2007, ANN SURG ONCOL, V14, P2010, DOI 10.1245/s10434-006-9198-2
  11. GABBERT HE, 1991, INT J CANCER, V49, P203, DOI 10.1002/ijc.2910490210
  12. Ikoma N, 2018, ANN SURG ONCOL, V25, P2012, DOI 10.1245/s10434-018-6471-0
  13. Japanese Gastric Canc Assoc, 2011, GASTRIC CANCER, V14, P113, DOI 10.1007/s10120-011-0042-4
  14. Jhawer M, 2009, AM J CLIN ONCOL-CANC, V32, P356, DOI 10.1097/COC.0b013e31818c08e8
  15. Katai H, 2018, GASTRIC CANCER, V21, P144, DOI 10.1007/s10120-017-0716-7
  16. Mansour JC, 2007, ANN SURG ONCOL, V14, P3412, DOI 10.1245/s10434-007-9574-6
  17. Meyer HJ, 2012, CHIRURG, V83, P31, DOI 10.1007/s00104-011-2149-x
  18. Ramos Marcus Fernando Kodama Pertille, 2018, Clinics, V73, pe543s, DOI 10.6061/clinics/2018/e543s
  19. Sasako M, 2008, NEW ENGL J MED, V359, P453, DOI 10.1056/NEJMoa0707035
  20. Schmidt T, 2014, BRIT J CANCER, V110, P1712, DOI 10.1038/bjc.2014.94
  21. Schuhmacher C, 2010, J CLIN ONCOL, V28, P5210, DOI 10.1200/JCO.2009.26.6114
  22. Schwartz LH, 2009, EUR J CANCER, V45, P261, DOI 10.1016/j.ejca.2008.10.028
  23. Seong H, 2013, DIGEST SURG, V30, P142
  24. Shi C, 2017, COLD REG SCI TECHNOL, V133, P15, DOI 10.1016/j.coldregions.2016.10.005
  25. Siegel R, 2014, CA-CANCER J CLIN, V64, P9, DOI 10.3322/caac.21208
  26. Smyth EC, 2016, J CLIN ONCOL, V34, P2721, DOI 10.1200/JCO.2015.65.7692
  27. Szor DJ, 2018, CLINICS, V73, DOI 10.6061/clinics/2018/e360
  28. Szor DJ, 2018, J SURG ONCOL, V117, P851, DOI 10.1002/jso.25036
  29. Valenti V, 2011, J SURG ONCOL, V104, P124, DOI 10.1002/jso.21947
  30. Wu LC, 2019, CANCER MANAG RES, V11, P6011, DOI 10.2147/CMAR.S203880
  31. Ychou M, 2011, J CLIN ONCOL, V29, P1715, DOI 10.1200/JCO.2010.33.0597

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/35
Artigos e Materiais de Revistas Científicas - ODS/03