Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study

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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2020
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
ANDRADE, Priscila Caldeira
BRASIL, Nissia Capello
JUNQUEIRA, Silvio Mauro
OLIVEIRA, Fernanda Maria Pirozelli de
RIBEIRO, Rodrigo Antonini
Citação
CLINICS, v.75, article ID e1588, 6p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS: A retrospective, single center study was conducted to collect real-world evidence of health outcomes and medication use in 247 obese patients (female, 82.2%) who underwent open Roux-en-Y gastric bypass. Changes in weight and body mass index (BMI), presence of apnea, hypertension, and type 2 diabetes (T2D), and medication use (hypertension, diabetes, and dyslipidemia) were assessed preoperatively and up to 24 months postoperatively. The mean cost of medications was calculated for the 12-month preoperative and 24-month postoperative periods. RESULTS: During the surgery, the mean age of patients was 43.42 years (standard deviation [SD], 10.9 years), and mean BMI was 46.7 kg/m(2) (SD, 6.7 kg/m(2)). At 24 months, significant declines were noted in weight (mean, 37.6 kg), BMI (mean, -14.3 kg/m(2)); presence of T2D, hypertension, and apnea (-29.6%, -50.6%, and -20.9%, respectively); and number of patients using medications (-66.67% for diabetes, -41.86% for hypertension, and 55.26% for dyslipidemia). The mean cost of medications (total costs for all medications) decreased by > 50% in 12-24 postoperative months compared to that in 12 preoperative months. CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System.
Palavras-chave
Open Roux-en-Y Gastric Bypass, Healthcare Costs, Real-World Evidence, Delivery of Healthcare
URI
https://observatorio.fm.usp.br/handle/OPI/35949
Referências
  1. Angrisani L, 2017, OBES SURG, V27, P2279, DOI 10.1007/s11695-017-2666-x
  2. Backes CF, 2016, SAO PAULO MED J, V134, P491, DOI 10.1590/1516-3180.2015.0241030516
  3. Barhouch AS, 2016, OBES SURG, V26, P1178, DOI 10.1007/s11695-015-1911-4
  4. Kelles SMB, 2014, ABCD-ARQ BRAS CIR DI, V27, P261, DOI 10.1590/S0102-67202014000400008
  5. Kelles SMB, 2011, SAO PAULO MED J, V129, P291, DOI 10.1590/S1516-31802011000500003
  6. Canadian Obesity Network-Reseau canadien en obesite, 2017, REP ACC OB TREATM AD
  7. Christou NV, 2009, CAN J SURG, V52, P229
  8. Colquitt JL, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003641.pub4
  9. Courcoulas AP, 2018, JAMA SURG, V153, P427, DOI 10.1001/jamasurg.2017.5025
  10. Douglas IJ, 2015, MEDICINE, V12, P12, DOI 10.1371/journal.pmed.1001809
  11. El-Kadre L, 2013, SURG OBES RELAT DIS, V9, P867, DOI 10.1016/j.soard.2013.01.020
  12. Gribsholt SB, 2017, ANN SURG, V265, P757, DOI 10.1097/SLA.0000000000001730
  13. JUNGES Vilma Maria, 2017, Arq. Gastroenterol., V54, P139, DOI [10.1590/S0004-2803.201700000-11, 10.1590/s0004-2803.201700000-11]
  14. Kelles SMB, 2014, BRAZ J MED BIOL RES, V47, P617, DOI 10.1590/1414-431X20143578
  15. Larsen AT, 2018, OBES SURG, V28, P338, DOI 10.1007/s11695-017-2834-z
  16. Ministerio da Saude, 2013, PORT 425 19 MARC 201
  17. Ministerio da Saude, 2013, PORT 424 19 MARC 201
  18. Santos LMP, 2010, OBES SURG, V20, P943, DOI 10.1007/s11695-008-9570-3
  19. Puzziferri N, 2014, JAMA-J AM MED ASSOC, V312, P934, DOI 10.1001/jama.2014.10706
  20. Raaijmakers LCH, 2017, EUR J CLIN NUTR, V71, P441, DOI 10.1038/ejcn.2016.198
  21. Rasera I, 2017, OBES SURG, V27, P536, DOI 10.1007/s11695-016-2439-y
  22. Ribeiro Emmeline Flor, 2015, GE Port J Gastroenterol, V22, P93, DOI 10.1016/j.jpge.2015.03.003
  23. Saleh Fady, 2016, CMAJ Open, V4, pE383
  24. Schauer P, 2003, SURG ENDOSC, V17, P212, DOI 10.1007/s00464-002-8857-z
  25. Shubeck S, 2018, JAMA-J AM MED ASSOC, V319, P302, DOI 10.1001/jama.2017.20521
  26. Sociedade Brasileira de Cirurgia Bariatrica e Metabolica, 2018, NUM CIRC BAR R BRAS

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/35
Artigos e Materiais de Revistas Científicas - ODS/03