LIM/05 - Laboratório de Poluição Atmosférica Experimental

URI Permanente desta comunidade

https://observatorio.fm.usp.br/handle/OPI/3614
O Laboratório de Poluição Atmosférica Experimental é ligado ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: patologia pulmonar; poluição atmosférica e seus efeitos sobre a saúde humana; toxicologia ambiental; fisiopatologia da lesão pulmonar aguda; mecânica pulmonar; imunopatologia e remodelamento da asma; patologia da doença pulmonar obstrutiva crônica; epidemiologia ambiental e educação ambiental; patologia pulmonar à autópsia.

Site oficial:http://limhc.fm.usp.br/portal/lim05-laboratorio-de-poluicao-atmosferica-experimental/

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article 0 Citação(ões) na Scopus
Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
article 1 Citação(ões) na Scopus
Providing support to underprivileged people during the COVID-19 pandemic in Brazil: the role of the Trust Group and women leaders in São Paulo’s favelas
(2023) DOMINGOS, A. L. G.; MITKIEWICZ, J. M.; SALDIVA, P. H. N.
São Paulo was one of the epicenters of the COVID-19 pandemic in Brazil. Amongst underprivileged populations, such as slums residents, the impact of the pandemic was severe. This documentary reports the creation of the Trust Group, made up mostly of women community leaders in São Paulo’s slums, and how their actions inspired public policies in Brazil. Their lessons are examples of governance and solidarity in times of crisis and can serve as models for other cities in Latin America. The documentary describes this history as told by those community leaders. To watch the documentary, kindly visit the following link: https://youtu.be/61elJw0oqCY.
article 7 Citação(ões) na Scopus
Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo
(2022) KE, W.; CHANDLER, M.; CEDRONE, E.; SAITO, R. F.; RANGEL, M. C.; JUNQUEIRA, M. De Souza; WANG, J.; SHI, D.; TRUONG, N.; RICHARDSON, M.; ROLBAND, L. A.; DRéAU, D.; BEDOCS, P.; CHAMMAS, R.; DOKHOLYAN, N. V.; DOBROVOLSKAIA, M. A.; AFONIN, K. A.
The unbalanced coagulation of blood is a life-threatening event that requires accurate and timely treatment. We introduce a user-friendly biomolecular platform based on modular RNA-DNA anticoagulant fibers programmed for reversible extracellular communication with thrombin and subsequent control of anticoagulation via a ""kill-switch""mechanism that restores hemostasis. To demonstrate the potential of this reconfigurable technology, we designed and tested a set of anticoagulant fibers that carry different thrombin-binding aptamers. All fibers are immunoquiescent, as confirmed in freshly collected human peripheral blood mononuclear cells. To assess interindividual variability, the anticoagulation is confirmed in the blood of human donors from the U.S. and Brazil. The anticoagulant fibers reveal superior anticoagulant activity and prolonged renal clearance in vivo in comparison to free aptamers. Finally, we confirm the efficacy of the ""kill-switch""mechanism in vivo in murine and porcine models.
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Protein Disulfide Isomerase overexpression induces mitochondrial reorganization and a differentiated VSMC phenotype: role of mitofusin-2
(2023) WOSNIAK JR., Joao; RODRIGUES, Rafael F. G.; KAKIMOTO, Pamela A.; SILVA, Camille C. Caldeira da; ANTUNES, Fernanda; STRAUSS, Bryan E.; KOWALTOWSKI, Alicia; LAURINDO, Francisco R.
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Treatment with empagliflozin improves cardiac function in infarcted animals associated with increased baroreflex sensitivity
(2023) SILVA, B. Da; NASCIMENTO-CARVALHO, B.; SOUZA, L. I. De; SILVA, M. B. Da; MARQUES, J. R.; DOURADO, P. M. M.; CONSOLIM-COLOMBO, F.; IRIGOYEN, M. C. C.
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FINE INHALABLE PARTICULATE MATTER (PM2.5) PRESENT IN AIR POLLUTION AND ITS EFFECTS ON MALE GERM CELLS CHROMATIN PACKAGING.
(2023) TAMASHIRO, Leticia Kaory; YARIWAKE, Victor Yuji; VERAS, Mariana Matera; BERTOLLA, Ricardo P.; INTASQUI, Paula
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THE INFLUENCE OF ENVIRONMENTAL FACTORS RELATING TO JUVENILE DERMATOMYOSITIS′S COURSE AND REFRACTORINESS TO TREATMENT
(2023) VALOES, Clarissa C. M.; ARABI, Tamima M. A.; BRAGA, Alfesio L. F.; FARHAT, Sylvia C. L.; SALLUM, Adriana M. E.
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Anthracosis particulate matter causes changes in macrophages inflammatory response and in expression of genes related to xenobiotics metabolism in co-culture of macrophages with BEAS-2B airway cells
(2023) FRIAS, Daniela Perroni; VIEIRA, Gabriela Lima; SMELAN, Juliana; LACERDA, Joao Paulo Amorim De; MAUAD, Thais; DOLHNIKOFF, Marisa; MACCHIONE, Mariangela
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Mapping of eosinophils, immune cell profiles, and microbes in COPD lung tissue
(2023) LINDO, Caroline; SIDDHURAJ, Premkumar; MAUCH, Renan; JONSSON, Jimmie; AHLGREN, Johan; JOGDAND, Prajakta; ANDERSSON, Cecilia; CANN, Jennifer; NAZAROFF, Christopher; LINDSTEDT, Sandra; MAUAD, Thais; SANDEN, Caroline; CRAE, Christopher Mc; ERJEFALT, Jonas S.
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Expression patterns of Interleukin-33 and its receptor ST2 in severe COVID-19
(2023) LINDO, Caroline; COSTA, Natalia De Souza Xavier; SIDDHURAJ, Premkumar; JONSSON, Jimmie; ORENGO, Jamie M.; SLEEMAN, Matthew A.; LINDSTEDT, Sandra; ANDERSSON, Cecilia; SILVA, Luiz Fernando; DUARTENETO, Armaro Nunes; SALDIVA, Paulo Hilario Nascimento; SANDEN, Caroline; MAUAD, Thais; ERJEFALT, Jonas